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BMC Pediatrics

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01-12-2020 | Septicemia | Research article

Late-onset neonatal sepsis in Suzhou, China

Authors: Tao Pan, Qiujiao Zhu, Pei Li, Jun Hua, Xing Feng

Published in: BMC Pediatrics | Issue 1/2020

Abstract

Background

This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period.

Methods

We performed a retrospective study on neonates with LOS from Jan1, 2011 to Dec 31, 2017. The demographic, clinical, and laboratory data of neonates with LOS were analyzed. Logistic regression was used to investigate the risk factors with mortality.

Results

During the study period, 202 neonates with LOS were finally identified. The most common pathogens were Escherichia coli (29.2%), followed by Klebsiella pneumoniae (19.3%), and Coagulase-negative Staphylococcus (CoNS) (16.8%). Nearly 90% of the K. pneumoniae were resistant to cefazolin and 71.8% to ceftazidime. Thirty-four patients (16.8%) died. Multivariable logistic regression showed that significant predictors of mortality were birth weight < 1500 g, respiratory distress and convulsions.

Conclusions

Gram-negative organisms have an important role in LOS in our region, with high levels of resistance to third-generation cephalosporins. These data may help in the selection of antibiotics for empirical treatment of neonates with sepsis.

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Title: Late-onset neonatal sepsis in Suzhou, China
Authors: Tao Pan
Qiujiao Zhu
Pei Li
Jun Hua
Xing Feng
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
Neonatal Sepsis
Antibiotic
Vancomycin
Cefazolin
Ceftazidime
Published in: BMC Pediatrics / Issue 1/2020
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-020-02103-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Late-onset neonatal sepsis in Suzhou, China

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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