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Published in: Trials 1/2020

Open Access 01-12-2020 | Septicemia | Letter

In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol

Authors: Christopher J. Lindsell, Anna McGlothlin, Samuel Nwosu, Todd W. Rice, Alex Hall, Gordon R. Bernard, Laurence W. Busse, E. Wesley Ely, Alpha A. Fowler, David F. Gaieski, Jeremiah S. Hinson, Michael H. Hooper, James C. Jackson, Gabor D. Kelen, Mark Levine, Greg S. Martin, Richard E. Rothman, Jonathan E. Sevransky, Kert Viele, David W. Wright, David N. Hager

Published in: Trials | Issue 1/2020

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Trial registration

ClinicalTrials.​gov: NCT03509350. Registered on 26 April 2018.
Literature
1.
Hager DN, Hooper MH, Bernard GR, Busse LW, Ely EW, Fowler AA, et al. The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. Trials. 2019;20(1):197.CrossRef
2.
Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–96.CrossRef
3.
Marik PE, Payen D. CITRIS-ALI: How statistics were used to obfuscate the true findings. Anaesth Crit Care Pa. 2019;38(6):575–7.CrossRef
4.
Brant EB, Angus DC. Is high-dose vitamin C beneficial for patients with sepsis? JAMA. 2019;322(13):1257–8.CrossRef
Metadata
Title
In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol
Authors
Christopher J. Lindsell
Anna McGlothlin
Samuel Nwosu
Todd W. Rice
Alex Hall
Gordon R. Bernard
Laurence W. Busse
E. Wesley Ely
Alpha A. Fowler
David F. Gaieski
Jeremiah S. Hinson
Michael H. Hooper
James C. Jackson
Gabor D. Kelen
Mark Levine
Greg S. Martin
Richard E. Rothman
Jonathan E. Sevransky
Kert Viele
David W. Wright
David N. Hager
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Trials / Issue 1/2020
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-020-04290-6

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