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Open Access 01-12-2021 | Septicemia | Research

Factors associated with mortality of pediatric sepsis patients at the pediatric intensive care unit in a low-resource setting

Authors: Desy Rusmawatiningtyas, Arini Rahmawati, Firdian Makrufardi, Nurul Mardhiah, Indah Kartika Murni, Cuno S. P. M. Uiterwaal, Ary I. Savitri, Intan Fatah Kumara, Nurnaningsih

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

Sepsis is the leading cause of death worldwide in pediatric populations. Studies in low-resource settings showed that the majority of pediatric patients with sepsis still have a high mortality rate.

Methods

We retrospectively collected records from 2014 to 2019 of patients who had been diagnosed with sepsis and admitted to PICU in our tertiary hospital. Cox proportional hazard regression modeling was used to evaluate associations between patient characteristics and mortality.

Results

Overall, 665 patients were enrolled in this study, with 364 (54.7%) boys and 301 (46.3%) girls. As many as 385 patients (57.9%) died during the study period. The median age of patients admitted to PICU were 1.8 years old with interquartile range (IQR) ±8.36 years and the median length of stay was 144 h (1–1896 h). More than half 391 patients (58.8%) had a good nutritional status. Higher risk of mortality in PICU was associated fluid overload percentage of > 10% (HR 9.6, 95% CI: 7.4–12.6), the need of mechanical ventilation support (HR 2.7, 95% CI: 1.6–4.6), vasoactive drugs (HR 1.5, 95% CI: 1.2–2.0) and the presence of congenital anomaly (HR 1.4, 95% CI: 1.0–1.9). On the contrary, cerebral palsy (HR 0.3, 95% CI: 0.1–0.5) and post-operative patients (HR 0.4, 95% CI: 0.3–0.6) had lower mortality.

Conclusion

PICU mortality in pediatric patients with sepsis is associated with fluid overload percentage of > 10%, the need for mechanical ventilation support, the need of vasoactive drugs, and the presence of congenital anomaly. In septic patients in PICU, those with cerebral palsy and admitted for post-operative care had better survival.

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Title: Factors associated with mortality of pediatric sepsis patients at the pediatric intensive care unit in a low-resource setting
Authors: Desy Rusmawatiningtyas
Arini Rahmawati
Firdian Makrufardi
Nurul Mardhiah
Indah Kartika Murni
Cuno S. P. M. Uiterwaal
Ary I. Savitri
Intan Fatah Kumara
Nurnaningsih
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Septicemia
Septicemia
Care
Pediatric Intensive Care
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02945-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Factors associated with mortality of pediatric sepsis patients at the pediatric intensive care unit in a low-resource setting

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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