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Critical Care
Published in: Critical Care 4/2008

01-08-2008 | Commentary

Sepsis therapy: what's the best for the mitochondria?

Authors: Florian Wagner, Peter Radermacher, Michael Georgieff, Enrico Calzia

Published in: Critical Care | Issue 4/2008

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Abstract

It is suspected that mitochondrial dysfunction is a major cause of organ failure in sepsis and septic shock. A study presented in this issue of Critical Care revealed that liver mitochondria from pigs treated with norepinephrine during endotoxaemia exhibit greater in vitro respiratory activity. The investigators provide an elegant demonstration of how therapeutic interventions in sepsis may profoundly influence mitochondrial respiration, but many aspects of mitochondrial function in sepsis remain to be clarified.
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Metadata
Title
Sepsis therapy: what's the best for the mitochondria?
Authors
Florian Wagner
Peter Radermacher
Michael Georgieff
Enrico Calzia
Publication date
01-08-2008
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2008
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc6964

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