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Critical Care
Published in: Critical Care 6/2009

01-12-2009 | Letter

Sepsis and multiple organ failure represent a chaotic adaptation to severe stress which must be controlled at nanoscale

Authors: Yusuf Alper Kilic, Ilke Kilic, Mesut Tez

Published in: Critical Care | Issue 6/2009

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Excerpt

Sepsis is a major healthcare problem causing significant mortality, morbidity and costs. Despite enormous efforts, a safe and reproducibly effective therapy for sepsis could not be found to date. …
Literature
1.
Abraham E, Singer M: Mechanisms of sepsis-induced organ dysfunction. Crit Care Med 2007, 35: 2408-2416. 10.1097/01.CCM.0000282072.56245.91CrossRefPubMed
2.
Singer M, De Santis V, Vitale D, Jeffcoate W: Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004, 364: 545-548. 10.1016/S0140-6736(04)16815-3CrossRefPubMed
3.
Saliba S, Kilic YA, Uranues S: Chaotic nature of sepsis and multiple organ failure cannot be explained by linear statistical methods. Crit Care 2008, 12: 417. 10.1186/cc6856PubMedCentralCrossRefPubMed
4.
Kilic YA, Yorganci K, Sayek I: Visualizing multiple organ failure: a method for analyzing temporal and dynamic relations between failing systems and interventions. Crit Care 2007, 11: 417. 10.1186/cc5941PubMedCentralCrossRefPubMed
5.
Metadata
Title
Sepsis and multiple organ failure represent a chaotic adaptation to severe stress which must be controlled at nanoscale
Authors
Yusuf Alper Kilic
Ilke Kilic
Mesut Tez
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2009
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc8140

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