Published in:
01-09-2006 | Original Article
Sentinel lymph node mapping for patients with Merkel cell carcinoma—experience of 5 years
Authors:
J. Liebau, A. Arens, V. Schwipper, A. Schulz
Published in:
European Journal of Plastic Surgery
|
Issue 3/2006
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Abstract
Merkel cell carcinoma (MCC) is a rare, highly malignant carcinoma of the neuroendocrinological system (Bayrou et al., J Am Acad Dermatol 24:198–207,
1992). It is a fast-growing, aggressive tumor with a high rate of local recurrence and early metastases. A radical surgical procedure is the therapy of choice. In case of lymph node metastases, regional lymphadenectomy is mandatory. Sentinel lymph node (SLN) mapping is a standard diagnostic technique to detect micrometastases in certain patients with malignant melanoma and breast cancer. The question is, can the SLN technique provide information as a prognostic factor and can the prognosis of the MCC be improved by detecting micrometastases in SLN at an early stage?