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European Radiology
Published in: European Radiology 11/2008

01-11-2008 | Computer Applications

Semi-automated measurement of hyperdense, hypodense and heterogeneous hepatic metastasis on standard MDCT slices. Comparison of semi-automated and manual measurement of RECIST and WHO criteria

Authors: Sebastian Keil, Florian F. Behrendt, Sven Stanzel, Michael Sühling, Alexander Koch, Jhenee Bubenzer, Georg Mühlenbruch, Andreas H. Mahnken, Rolf W. Günther, Marco Das

Published in: European Radiology | Issue 11/2008

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Abstract

As semi-automated measurement would be desirable for lesion quantification and therapy-response control, the purpose of this study was to compare semi-automated measurements with manual assessment of different types of hepatic metastases. Seventy-six patients with known liver metastases were analysed. All of them underwent contrast-enhanced 16-MDCT (16 × 0.75 mm collimation, 120 kV, 0.5 s rotation time, 160 mAseff) for evaluation of follow-up status. On the basis of standard reconstructed 5-mm slices (in 4-mm increments), each lesion was quantified based on RECIST and WHO criteria using a semi-automated software tool (Syngo Oncology) and also manually by an experienced radiologist. Results from the software were compared to manual measurements. Statistical analysis was performed applying the concordance correlation coefficient, and results were represented graphically in Bland-Altman plots. A total of 52 hyperdense, 57 hypodense and 56 heterogeneous metastases were found and correctly measured by the software. All three lesion types revealed a strong correlation agreement between measurement techniques [RECIST diameter: 0.93 (hyperdense), 0.95(hypodense), 0.94 (heterogeneous); WHO area: 0.95, 0.98, 0.93]. Semi-automatic measurement of hyperdense, hypodense and heterogeneous liver metastases showed reliable results on standard axial reconstructions in comparison to manual quantification.
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Metadata
Title
Semi-automated measurement of hyperdense, hypodense and heterogeneous hepatic metastasis on standard MDCT slices. Comparison of semi-automated and manual measurement of RECIST and WHO criteria
Authors
Sebastian Keil
Florian F. Behrendt
Sven Stanzel
Michael Sühling
Alexander Koch
Jhenee Bubenzer
Georg Mühlenbruch
Andreas H. Mahnken
Rolf W. Günther
Marco Das
Publication date
01-11-2008
Publisher
Springer-Verlag
Published in
European Radiology / Issue 11/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-008-1050-6

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