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BMC Cancer
Published in: BMC Cancer 1/2009

Open Access 01-12-2009 | Research article

Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells

Authors: Rizky Abdulah, Ahmad Faried, Kenji Kobayashi, Chiho Yamazaki, Eka W Suradji, Kazuto Ito, Kazuhiro Suzuki, Masami Murakami, Hiroyuki Kuwano, Hiroshi Koyama

Published in: BMC Cancer | Issue 1/2009

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Abstract

Background

Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts.

Method

Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract.

Results

Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway.

Conclusion

Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy.
Appendix
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Metadata
Title
Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
Authors
Rizky Abdulah
Ahmad Faried
Kenji Kobayashi
Chiho Yamazaki
Eka W Suradji
Kazuto Ito
Kazuhiro Suzuki
Masami Murakami
Hiroyuki Kuwano
Hiroshi Koyama
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2009
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-9-414

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