Skip to main content
Top
Published in: Cancer Causes & Control 12/2017

01-12-2017 | Original paper

Sedentary time and postmenopausal breast cancer incidence

Authors: Sarah J. O. Nomura, Chiranjeev Dash, Vanessa B. Sheppard, Deborah Bowen, Matthew Allison, Wendy Barrington, Rowan Chlebowski, Mace Coday, Lifang Hou, Barbara Howard, Michael LaMonte, JoAnn E. Manson, Marian L. Neuhouser, Electra Paskett, Maryam Sattari, Marcia Stefanick, Jean Wactawski-Wende, Lucile L. Adams-Campbell

Published in: Cancer Causes & Control | Issue 12/2017

Login to get access

Abstract

Purpose

The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements.

Methods

The Women’s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity.

Results

Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements.

Conclusions

Results from this study do not support an association between sedentary time and breast cancer incidence.
Appendix
Available only for authorised users
Literature
9.
go back to reference U.S. Department of Health and Human Services (2008) 2008 Physical activity guidelines for Americans. U.S. Department of Health and Human Services, Washington, DC U.S. Department of Health and Human Services (2008) 2008 Physical activity guidelines for Americans. U.S. Department of Health and Human Services, Washington, DC
14.
go back to reference Lynch BM, Friedenreich CM, Winkler EA, Healy GN, Vallance JK, Eakin EG, Owen N (2011) Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003–2006). Breast Cancer Res Treat 130(1):183–194. doi:10.1007/s10549-011-1559-2 CrossRefPubMed Lynch BM, Friedenreich CM, Winkler EA, Healy GN, Vallance JK, Eakin EG, Owen N (2011) Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003–2006). Breast Cancer Res Treat 130(1):183–194. doi:10.​1007/​s10549-011-1559-2 CrossRefPubMed
15.
go back to reference Wiseman AJ, Lynch BM, Cameron AJ, Dunstan DW (2014) Associations of change in television viewing time with biomarkers of postmenopausal breast cancer risk: the Australian Diabetes, Obesity and Lifestyle Study. Cancer Causes Control 25(10):1309–1319. doi:10.1007/s10552-014-0433-z CrossRefPubMed Wiseman AJ, Lynch BM, Cameron AJ, Dunstan DW (2014) Associations of change in television viewing time with biomarkers of postmenopausal breast cancer risk: the Australian Diabetes, Obesity and Lifestyle Study. Cancer Causes Control 25(10):1309–1319. doi:10.​1007/​s10552-014-0433-z CrossRefPubMed
16.
go back to reference DeSantis CE, Fedewa SA, Goding Sauer A, Kramer JL, Smith RA, Jemal A (2016) Breast cancer statistics, 2015: convergence of incidence rates between black and white women. CA Cancer J Clin 66(1):31–42. doi:10.3322/caac.21320 CrossRefPubMed DeSantis CE, Fedewa SA, Goding Sauer A, Kramer JL, Smith RA, Jemal A (2016) Breast cancer statistics, 2015: convergence of incidence rates between black and white women. CA Cancer J Clin 66(1):31–42. doi:10.​3322/​caac.​21320 CrossRefPubMed
17.
go back to reference Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL, Gaudet M, Schmidt MK, Broeks A, Cox A, Fasching PA, Hein R, Spurdle AB, Blows F, Driver K, Flesch-Janys D, Heinz J, Sinn P, Vrieling A, Heikkinen T, Aittomaki K, Heikkila P, Blomqvist C, Lissowska J, Peplonska B, Chanock S, Figueroa J, Brinton L, Hall P, Czene K, Humphreys K, Darabi H, Liu JJ, Van ‘t Veer LJ, Van Leeuwen FE, Andrulis IL, Glendon G, Knight JA, Mulligan AM, O’Malley FP, Weerasooriya N, John EM, Beckmann MW, Hartmann A, Weihbrecht SB, Wachter DL, Jud SM, Loehberg CR, Baglietto L, English DR, Giles GG, McLean CA, Severi G, Lambrechts D, Vandorpe T, Weltens C, Paridaens R, Smeets A, Neven P, Wildiers H, Wang XS, Olson JE, Cafourek V, Fredericksen Z, Kosel M, Vachon C, Cramp HE, Connley D, Cross SS, Balasubramanian SP, Reed MWR, Dork T, Bremer M, Meyer A, Karstens JH, Ay A, Park-Simon TW, Hillemanns P, Perez JIA, Rodriguez PM, Zamora P, Bentez J, Ko YD, Fischer HP, Hamann U, Pesch B, Bruning T, Justenhoven C, Brauch H, Eccles DM, Tapper WJ, Gerty SM, Sawyer EJ, Tomlinson IP, Jones A, Kerin M, Miller N, McInerney N, Anton-Culver H, Ziogas A, Shen CY, Hsiung CN, Wu PE, Yang SL, Yu JC, Chen ST, Hsu GC, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Lindblom A, Margolin S, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Gorski B, Gronwald J, Hooning MJ, Hollestelle A, van den Ouweland AMW, Jager A, Kriege M, Tilanus-Linthorst MMA, Collee M, Wang-Gohrke S, Pylkas K, Jukkola-Vuorinen A, Mononen K, Grip M, Hirvikoski P, Winqvist R, Mannermaa A, Kosma VM, Kauppinen J, Kataja V, Auvinen P, Soini Y, Sironen R, Bojesen SE, Orsted DD, Kaur-Knudsen D, Flyger H, Nordestgaard BG, Holland H, Chenevix-Trench G, Manoukian S, Barile M, Radice P, Hankinson SE, Hunter DJ, Tamimi R, Sangrajrang S, Brennan P, Mckay J, Odefrey F, Gaborieau V, Devilee P, Huijts PEA, Tollenaar RAEM, Seynaeve C, Dite GS, Apicella C, Hopper JL, Hammet F, Tsimiklis H, Smith LD, Southey MC, Humphreys MK, Easton D, Pharoah P, Sherman ME, Garcia-Closas M (2011) Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the breast cancer association consortium studies. J Natl Cancer Inst 103 (3):250–263. doi:10.1093/jnci/djq526 CrossRefPubMed Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL, Gaudet M, Schmidt MK, Broeks A, Cox A, Fasching PA, Hein R, Spurdle AB, Blows F, Driver K, Flesch-Janys D, Heinz J, Sinn P, Vrieling A, Heikkinen T, Aittomaki K, Heikkila P, Blomqvist C, Lissowska J, Peplonska B, Chanock S, Figueroa J, Brinton L, Hall P, Czene K, Humphreys K, Darabi H, Liu JJ, Van ‘t Veer LJ, Van Leeuwen FE, Andrulis IL, Glendon G, Knight JA, Mulligan AM, O’Malley FP, Weerasooriya N, John EM, Beckmann MW, Hartmann A, Weihbrecht SB, Wachter DL, Jud SM, Loehberg CR, Baglietto L, English DR, Giles GG, McLean CA, Severi G, Lambrechts D, Vandorpe T, Weltens C, Paridaens R, Smeets A, Neven P, Wildiers H, Wang XS, Olson JE, Cafourek V, Fredericksen Z, Kosel M, Vachon C, Cramp HE, Connley D, Cross SS, Balasubramanian SP, Reed MWR, Dork T, Bremer M, Meyer A, Karstens JH, Ay A, Park-Simon TW, Hillemanns P, Perez JIA, Rodriguez PM, Zamora P, Bentez J, Ko YD, Fischer HP, Hamann U, Pesch B, Bruning T, Justenhoven C, Brauch H, Eccles DM, Tapper WJ, Gerty SM, Sawyer EJ, Tomlinson IP, Jones A, Kerin M, Miller N, McInerney N, Anton-Culver H, Ziogas A, Shen CY, Hsiung CN, Wu PE, Yang SL, Yu JC, Chen ST, Hsu GC, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Lindblom A, Margolin S, Jakubowska A, Lubinski J, Huzarski T, Byrski T, Gorski B, Gronwald J, Hooning MJ, Hollestelle A, van den Ouweland AMW, Jager A, Kriege M, Tilanus-Linthorst MMA, Collee M, Wang-Gohrke S, Pylkas K, Jukkola-Vuorinen A, Mononen K, Grip M, Hirvikoski P, Winqvist R, Mannermaa A, Kosma VM, Kauppinen J, Kataja V, Auvinen P, Soini Y, Sironen R, Bojesen SE, Orsted DD, Kaur-Knudsen D, Flyger H, Nordestgaard BG, Holland H, Chenevix-Trench G, Manoukian S, Barile M, Radice P, Hankinson SE, Hunter DJ, Tamimi R, Sangrajrang S, Brennan P, Mckay J, Odefrey F, Gaborieau V, Devilee P, Huijts PEA, Tollenaar RAEM, Seynaeve C, Dite GS, Apicella C, Hopper JL, Hammet F, Tsimiklis H, Smith LD, Southey MC, Humphreys MK, Easton D, Pharoah P, Sherman ME, Garcia-Closas M (2011) Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the breast cancer association consortium studies. J Natl Cancer Inst 103 (3):250–263. doi:10.​1093/​jnci/​djq526 CrossRefPubMed
19.
go back to reference Jung S, Spiegelman D, Baglietto L, Bernstein L, Boggs DA, van den Brandt PA, Buring JE, Cerhan JR, Gaudet MM, Giles GG, Goodman G, Hakansson N, Hankinson SE, Helzlsouer K, Horn-Ross PL, Inoue M, Krogh V, Lof M, McCullough ML, Miller AB, Neuhouser ML, Palmer JR, Park Y, Robien K, Rohan TE, Scarmo S, Schairer C, Schouten LJ, Shikany JM, Sieri S, Tsugane S, Visvanathan K, Weiderpass E, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Zhang SM, Zhang X, Ziegler RG, Smith-Warner SA (2013) Fruit and vegetable intake and risk of breast cancer by hormone receptor status. J Natl Cancer Inst 105(3):219–236. doi:10.1093/jnci/djs635 CrossRefPubMedPubMedCentral Jung S, Spiegelman D, Baglietto L, Bernstein L, Boggs DA, van den Brandt PA, Buring JE, Cerhan JR, Gaudet MM, Giles GG, Goodman G, Hakansson N, Hankinson SE, Helzlsouer K, Horn-Ross PL, Inoue M, Krogh V, Lof M, McCullough ML, Miller AB, Neuhouser ML, Palmer JR, Park Y, Robien K, Rohan TE, Scarmo S, Schairer C, Schouten LJ, Shikany JM, Sieri S, Tsugane S, Visvanathan K, Weiderpass E, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Zhang SM, Zhang X, Ziegler RG, Smith-Warner SA (2013) Fruit and vegetable intake and risk of breast cancer by hormone receptor status. J Natl Cancer Inst 105(3):219–236. doi:10.​1093/​jnci/​djs635 CrossRefPubMedPubMedCentral
20.
go back to reference Cohen SS, Matthews CE, Bradshaw PT, Lipworth L, Buchowski MS, Signorello LB, Blot WJ (2013) Sedentary behavior, physical activity, and likelihood of breast cancer among Black and White women: a report from the Southern Community Cohort Study. Cancer Prev Res 6(6):566–576. doi:10.1158/1940-6207.CAPR-13-0045 CrossRef Cohen SS, Matthews CE, Bradshaw PT, Lipworth L, Buchowski MS, Signorello LB, Blot WJ (2013) Sedentary behavior, physical activity, and likelihood of breast cancer among Black and White women: a report from the Southern Community Cohort Study. Cancer Prev Res 6(6):566–576. doi:10.​1158/​1940-6207.​CAPR-13-0045 CrossRef
23.
go back to reference Chomistek AK, Manson JE, Stefanick ML, Lu B, Sands-Lincoln M, Going SB, Garcia L, Allison MA, Sims ST, LaMonte MJ, Johnson KC, Eaton CB (2013) Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women’s Health Initiative. J Am Coll Cardiol 61(23):2346–2354. doi:10.1016/j.jacc.2013.03.031 CrossRefPubMedPubMedCentral Chomistek AK, Manson JE, Stefanick ML, Lu B, Sands-Lincoln M, Going SB, Garcia L, Allison MA, Sims ST, LaMonte MJ, Johnson KC, Eaton CB (2013) Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women’s Health Initiative. J Am Coll Cardiol 61(23):2346–2354. doi:10.​1016/​j.​jacc.​2013.​03.​031 CrossRefPubMedPubMedCentral
24.
go back to reference Paxton RJ, Jung SY, Vitolins MZ, Fenton J, Paskett E, Pollak M, Hays-Grudo J, Hursting SD, Chang S (2014) Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers. Cancer Causes Control 25(11):1427–1437. doi:10.1007/s10552-014-0434-y CrossRefPubMedPubMedCentral Paxton RJ, Jung SY, Vitolins MZ, Fenton J, Paskett E, Pollak M, Hays-Grudo J, Hursting SD, Chang S (2014) Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers. Cancer Causes Control 25(11):1427–1437. doi:10.​1007/​s10552-014-0434-y CrossRefPubMedPubMedCentral
25.
go back to reference Langer RD, White E, Lewis CE, Kotchen JM, Hendrix SL, Trevisan M (2003) The women’s health initiative observational study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol 13(9 Suppl):S107-121 Langer RD, White E, Lewis CE, Kotchen JM, Hendrix SL, Trevisan M (2003) The women’s health initiative observational study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol 13(9 Suppl):S107-121
27.
go back to reference Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T (1999) Measurement characteristics of the Women’s Health Initiative food frequency questionnaire. Ann Epidemiol 9(3):178–187CrossRefPubMed Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T (1999) Measurement characteristics of the Women’s Health Initiative food frequency questionnaire. Ann Epidemiol 9(3):178–187CrossRefPubMed
29.
go back to reference George SM, Irwin ML, Smith AW, Neuhouser ML, Reedy J, McTiernan A, Alfano CM, Bernstein L, Ulrich CM, Baumgartner KB, Moore SC, Albanes D, Mayne ST, Gail MH, Ballard-Barbash R (2011) Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer. Cancer Causes Control 22(4):589–598. doi:10.1007/s10552-011-9732-9 CrossRefPubMedPubMedCentral George SM, Irwin ML, Smith AW, Neuhouser ML, Reedy J, McTiernan A, Alfano CM, Bernstein L, Ulrich CM, Baumgartner KB, Moore SC, Albanes D, Mayne ST, Gail MH, Ballard-Barbash R (2011) Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer. Cancer Causes Control 22(4):589–598. doi:10.​1007/​s10552-011-9732-9 CrossRefPubMedPubMedCentral
30.
go back to reference Curb JD, McTiernan A, Heckbert SR, Kooperberg C, Stanford J, Nevitt M, Johnson KC, Proulx-Burns L, Pastore L, Criqui M, Daugherty S, Morbidity WHI, Mortality C (2003) Outcomes ascertainment and adjudication methods in the Women’s Health Initiative. Ann Epidemiol 13(9 Suppl):S122-128 Curb JD, McTiernan A, Heckbert SR, Kooperberg C, Stanford J, Nevitt M, Johnson KC, Proulx-Burns L, Pastore L, Criqui M, Daugherty S, Morbidity WHI, Mortality C (2003) Outcomes ascertainment and adjudication methods in the Women’s Health Initiative. Ann Epidemiol 13(9 Suppl):S122-128
32.
go back to reference Wang A, Qin F, Hedlin H, Desai M, Chlebowski R, Gomez S, Eaton CB, Johnson KC, Qi L, Wactawski-Wende J, Womack C, Wakelee HA, Stefanick ML (2016) Physical activity and sedentary behavior in relation to lung cancer incidence and mortality in older women: the Women’s Health Initiative. Int J Cancer 139(10):2178–2192. doi:10.1002/ijc.30281 CrossRefPubMedPubMedCentral Wang A, Qin F, Hedlin H, Desai M, Chlebowski R, Gomez S, Eaton CB, Johnson KC, Qi L, Wactawski-Wende J, Womack C, Wakelee HA, Stefanick ML (2016) Physical activity and sedentary behavior in relation to lung cancer incidence and mortality in older women: the Women’s Health Initiative. Int J Cancer 139(10):2178–2192. doi:10.​1002/​ijc.​30281 CrossRefPubMedPubMedCentral
33.
go back to reference World Health Organization (2010) Global Recommendations on Physical Activity for Health. World Health Organization, Switzerland World Health Organization (2010) Global Recommendations on Physical Activity for Health. World Health Organization, Switzerland
34.
go back to reference World Health Organization (2011) Waist Circumference and Waist-Hip Ratio. Report of a WHO Expert Consultation, Geneva, 8–11 December 2008. WHO Document Production Services, Geneva World Health Organization (2011) Waist Circumference and Waist-Hip Ratio. Report of a WHO Expert Consultation, Geneva, 8–11 December 2008. WHO Document Production Services, Geneva
36.
go back to reference Matthews CE, Keadle SK, Troiano RP, Kahle L, Koster A, Brychta R, Van Domelen D, Caserotti P, Chen KY, Harris TB, Berrigan D (2016) Accelerometer-measured dose-response for physical activity, sedentary time, and mortality in US adults. Am J Clin Nutr 104(5):1424–1432. doi:10.3945/ajcn.116.135129 CrossRefPubMedPubMedCentral Matthews CE, Keadle SK, Troiano RP, Kahle L, Koster A, Brychta R, Van Domelen D, Caserotti P, Chen KY, Harris TB, Berrigan D (2016) Accelerometer-measured dose-response for physical activity, sedentary time, and mortality in US adults. Am J Clin Nutr 104(5):1424–1432. doi:10.​3945/​ajcn.​116.​135129 CrossRefPubMedPubMedCentral
37.
go back to reference Blanck HM, McCullough ML, Patel AV, Gillespie C, Calle EE, Cokkinides VE, Galuska DA, Khan LK, Serdula MK (2007) Sedentary behavior, recreational physical activity, and 7-year weight gain among postmenopausal U.S. women. Obesity (Silver Spring) 15(6):1578–1588. doi:10.1038/oby.2007.187 CrossRef Blanck HM, McCullough ML, Patel AV, Gillespie C, Calle EE, Cokkinides VE, Galuska DA, Khan LK, Serdula MK (2007) Sedentary behavior, recreational physical activity, and 7-year weight gain among postmenopausal U.S. women. Obesity (Silver Spring) 15(6):1578–1588. doi:10.​1038/​oby.​2007.​187 CrossRef
40.
go back to reference Helmerhorst HJ, Wijndaele K, Brage S, Wareham NJ, Ekelund U (2009) Objectively measured sedentary time may predict insulin resistance independent of moderate- and vigorous-intensity physical activity. Diabetes 58(8):1776–1779. doi:10.2337/db08-1773 CrossRefPubMedPubMedCentral Helmerhorst HJ, Wijndaele K, Brage S, Wareham NJ, Ekelund U (2009) Objectively measured sedentary time may predict insulin resistance independent of moderate- and vigorous-intensity physical activity. Diabetes 58(8):1776–1779. doi:10.​2337/​db08-1773 CrossRefPubMedPubMedCentral
43.
go back to reference Lynch BM, Dunstan DW, Healy GN, Winkler E, Eakin E, Owen N (2010) Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006). Cancer Causes Control 21(2):283–288. doi:10.1007/s10552-009-9460-6 CrossRefPubMed Lynch BM, Dunstan DW, Healy GN, Winkler E, Eakin E, Owen N (2010) Objectively measured physical activity and sedentary time of breast cancer survivors, and associations with adiposity: findings from NHANES (2003–2006). Cancer Causes Control 21(2):283–288. doi:10.​1007/​s10552-009-9460-6 CrossRefPubMed
Metadata
Title
Sedentary time and postmenopausal breast cancer incidence
Authors
Sarah J. O. Nomura
Chiranjeev Dash
Vanessa B. Sheppard
Deborah Bowen
Matthew Allison
Wendy Barrington
Rowan Chlebowski
Mace Coday
Lifang Hou
Barbara Howard
Michael LaMonte
JoAnn E. Manson
Marian L. Neuhouser
Electra Paskett
Maryam Sattari
Marcia Stefanick
Jean Wactawski-Wende
Lucile L. Adams-Campbell
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 12/2017
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-017-0968-x

Other articles of this Issue 12/2017

Cancer Causes & Control 12/2017 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine