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International Journal of Colorectal Disease

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01-06-2011 | Original Article

Sedation, analgesia, and cardiorespiratory function in colonoscopy using midazolam combined with fentanyl or propofol

Authors: Fen Wang, Shou-Rong Shen, Ding-Hua Xiao, Can-Xia Xu, Wu-Liang Tang

Published in: International Journal of Colorectal Disease | Issue 6/2011

Abstract

Background and aims

The use of sedatives during colonoscopy remains controversial because of its safety concerns. We compared cardiorespiratory function and sedative and analgesic effects in sedative colonoscopy, using combinations of midazolam with either fentanyl or propofol.

Methods

Eligible patients (n = 480) received 1.0–2.0 mg midazolam alone (n = 160), midazolam combined with either 50–100 mg fentanyl intramuscularly (n = 160), or 0.5–2.5 mg/kg propofol intravenously, as premedication for sedative colonoscopy. Pulse rate, blood pressure, and saturation of peripheral oxygen (SpO₂) were monitored. Levels of sedation and analgesia were semi-quantitatively scored using visual analog scales, and amnesia profiles were qualitatively evaluated.

Results

Combining midazolam with either fentanyl or propofol resulted in acceptable sedative and analgesic effects compared to treatment with midazolam alone (P < 0.001), with the combination with propofol giving more favorable results. More patients receiving the propofol combination became amnestic to the procedure than patients receiving the fentanyl combination. However, midazolam combined with propofol disturbed the pulse rate (P < 0.05) and blood pressure (P < 0.001) more significantly than a combination with fentanyl, or midazolam alone.

Conclusion

The combination of midazolam with either fentanyl or propofol allowed patients to undergo colonoscopy under comparable sedative and analgesic conditions. The combination with fentanyl had a significantly lower effect on pulse rate and blood pressure. The combination with propofol produced superior amnestic effects.

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Title: Sedation, analgesia, and cardiorespiratory function in colonoscopy using midazolam combined with fentanyl or propofol
Authors: Fen Wang
Shou-Rong Shen
Ding-Hua Xiao
Can-Xia Xu
Wu-Liang Tang
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 6/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-011-1162-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sedation, analgesia, and cardiorespiratory function in colonoscopy using midazolam combined with fentanyl or propofol

Abstract

Background and aims

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and aims

Methods

Results

Conclusion

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