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Cancer Causes & Control

Published in:

01-02-2012 | Original Paper

Seaweed intake and urinary sex hormone levels in preschool Japanese children

Authors: Keiko Wada, Kozue Nakamura, Yuya Tamai, Michiko Tsuji, Kaori Watanabe, Kyoko Ando, Chisato Nagata

Published in: Cancer Causes & Control | Issue 2/2012

Abstract

Purpose

We investigated whether seaweed intake is associated with sex steroid levels in young Japanese children.

Methods

The design of the study was cross-sectional and it was conducted in October–November 2006. Subjects were substantially healthy preschoolers, 230 boys and 198 girls, aged 3–6 years. Dietary data, including seaweed intake, were assessed using 3-day dietary records covering 2 consecutive weekdays and 1 weekend day. Urinary estrone, estradiol, testosterone, and 5-androstene-3β,17α diol levels were measured by liquid chromatography–electrospray ionization tandem mass spectrometry. Urinary dehydroepiandrosterone level was measured with a radioimmunoassay. Steroid hormones were adjusted for urinary creatinine levels.

Results

Spearman’s correlation coefficient between seaweed intake and estrone level was −0.144 (p = 0.030) in boys and −0.147 (p = 0.041) in girls after adjustments for age, BMI, and total energy intake. Seaweed intake was neither associated with estradiol, testosterone, 3β,17α-AED nor with DHEA among boys and girls.

Conclusions

The negative association between seaweed intake and estrone level suggests that dietary seaweed intake might affect estrogen metabolism in childhood.

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Title: Seaweed intake and urinary sex hormone levels in preschool Japanese children
Authors: Keiko Wada
Kozue Nakamura
Yuya Tamai
Michiko Tsuji
Kaori Watanabe
Kyoko Ando
Chisato Nagata
Publication date: 01-02-2012
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 2/2012
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-011-9871-z

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Abstract

Purpose

Methods

Results

Conclusions

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