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01-08-2010 | Correspondence

SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: which manoeuvre is evidence-based?

Authors: Luciano Silvestri, Hendrick K. F. van Saene, Durk F. Zandstra, Marino Viviani, Dario Gregori

Published in: Intensive Care Medicine | Issue 8/2010

Excerpt

Dear editor: We read with interest the editorial by Segers and de Mol on the prevention of ventilator-associated pneumonia (VAP) after cardiac surgery [1]. We would like to comment on the authors’ statements on the use of selective digestive decontamination (SDD), selective oropharyngeal decontamination (SOD), and oropharyngeal chlorhexidine, as they are based on inaccurate interpretation of the evidence. …

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Segers P, de Mol B (2009) Prevention of ventilator-associated pneumonia after cardiac surgery: prepare and defend! Intensive Care Med 35:1497–1499CrossRefPubMed

de Smet AM, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS, van der Hoeven JG, Pickkers P, Bogaers-Hofman D, van der Meer NJ, Bernards AT, Kuijper EJ, Joore JC, Leverstein-van Hall MA, Bindels AJ, Jansz AR, Wesselink RM, de Jongh BM, Dennesen PJ, van Asselt GJ, te Velde LF, Frenay IH, Kaasjager K, Bosch FH, van Iterson M, Thijsen SF, Kluge GH, Pauw W, de Vries JW, Kaan JA, Arends JP, Aarts LP, Sturm PD, Harinck HI, Voss A, Uijtendaal EV, Blok HE, Thieme Groen ES, Pouw ME, Kalkman CJ, Bonten MJ (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20–31CrossRefPubMed

Liberati A, D’Amico R, Pifferi S, Torri V, Brazzi L, Parmelli E (2009) Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev 7:CD000022

Silvestri L, van Saene HK, Milanese M, Gregori D, Gullo A (2007) Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized controlled trials. J Hosp Infect 65:187–203CrossRefPubMed

Silvestri L, van Saene HK, Weir I, Gullo A (2009) Survival benefit of the full selective digestive decontamination regimen. J Crit Care 24:474.e7–e14

Title: SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: which manoeuvre is evidence-based?
Authors: Luciano Silvestri
Hendrick K. F. van Saene
Durk F. Zandstra
Marino Viviani
Dario Gregori
Publication date: 01-08-2010
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 8/2010
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-1809-5

At a glance: The STEP trials

Springer Medicine

SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: which manoeuvre is evidence-based?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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