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01-12-2015 | Original Article

Sciellin is a marker for papillary renal cell tumours

Authors: Anetta Nagy, Daniel Banyai, David Semjen, Tamas Beothe, Gyula Kovacs

Published in: Virchows Archiv | Issue 6/2015

Abstract

There are no adequate immunohistochemical markers for papillary renal cell tumours. The aim of this study was to establish a gene expression profile of papillary renal cell tumours using an expression microarray approach. Through hierarchical clustering and significant analysis of microarrays, we have selected the best 13 genes and analysed their expression by real-time polymerase chain reaction (RT-PCR). Of these genes, we selected SCEL as potential marker of interest. Immunohistochemical staining of tissue microarrays containing all major types of kidney cancers revealed positive staining for sciellin in 87 of 114 papillary renal cell tumours and in 13 of 19 precursor lesions. No other renal tumour types were positive for sciellin. Our study indicates that although not all tumours express sciellin, its expression may help to confirm the diagnosis papillary renal cell tumour.

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Title: Sciellin is a marker for papillary renal cell tumours
Authors: Anetta Nagy
Daniel Banyai
David Semjen
Tamas Beothe
Gyula Kovacs
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 6/2015
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-015-1856-y

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Sciellin is a marker for papillary renal cell tumours

Abstract

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