Top

Published in:

01-12-2006 | Original Article

Saturation biopsy protocol enhances prediction of pT3 and surgical margin status on prostatectomy specimen

Authors: Aurélien Descazeaud, Mark Rubin, Stéphanie Chemama, Stéphane Larré, Laurent Salomon, Yves Allory, Dimitri Vordos, Andras Hoznek, René Yiou, Dominique Chopin, Claude Abbou, Alexandre de la Taille

Published in: World Journal of Urology | Issue 6/2006

Abstract

A 21-samples saturation biopsy procedure (SBP) was developed in order to improve prostate cancer detection rate. Out of 650 patients who underwent this protocol, 150 had a clinically localized prostate cancer and underwent a radical prostatectomy. The number of cores positive for tumor was assessed in the SBP, and also in the sextant component of the SBP (SC) and in the non-sextant component of the SBP (NSC). Numbers of cores positive for tumor on SBP, SC, and NSC were significantly higher in pT3 group versus pT2 (P < 0.001 each) and in positive surgical margins (PSM) group versus no PSM (P < 0.001 each). When comparing area under the curve obtained from SBP with those obtained from NSC and SC, the SBP showed higher accuracy than the NSC and the SC for the prediction of pT3 and PSM. On multivariate analyses, SC and NSC were independent predictors of pT3 and PSM on radical prostatectomy.

Ackerman DA et al (1993) Analysis of risk factors associated with prostate cancer extension to the surgical margin and pelvic node metastasis at radical prostatectomy. J Urol 150(6):1845–1850PubMed

Che M, Sakr W, Grignon D (2003) Pathologic features the urologist should expect on a prostate biopsy. Urol Oncol 21(2):153–161PubMed

Cheng L et al (2000) Preoperative prediction of surgical margin status in patients with prostate cancer treated by radical prostatectomy. J Clin Oncol 18(15):2862–2868PubMed

Gancarczyk KJ et al (2003) Using the percentage of biopsy cores positive for cancer, pretreatment PSA, and highest biopsy Gleason sum to predict pathologic stage after radical prostatectomy: the Center for Prostate Disease Research nomograms. Urology 61(3):589–595CrossRefPubMed

Hodge KK et al (1989) Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate. J Urol 142(1):71–74; discussion 74–75

Lotan Y et al (2004) The percent of biopsy cores positive for cancer is a predictor of advanced pathological stage and poor clinical outcomes in patients treated with radical prostatectomy. J Urol 171(6Pt1):2209–2214CrossRefPubMed

Naya Y et al (2004) A comparison of extended biopsy and sextant biopsy schemes for predicting the pathological stage of prostate cancer. J Urol 171(6Pt1):2203–2208CrossRefPubMed

Ohori M et al (2004) Radical prostatectomy for carcinoma of the prostate. Mod Pathol 17(3):349–359CrossRefPubMed

Ohori M et al (2004) Predicting the presence and side of extracapsular extension: a nomogram for staging prostate cancer. J Urol 171(5):1844–1849; discussion 1849

10.

Partin AW, Walsh PC (1994) Re: The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer. J Urol 152(1):172–173PubMed

11.

Peller PA et al (1995) Sextant prostate biopsies. A histopathologic correlation with radical prostatectomy specimens. Cancer 75(2):530–538CrossRefPubMed

12.

Ross PL, Scardino PT, Kattan MW (2001) A catalog of prostate cancer nomograms. J Urol 165(5):1562–1568CrossRefPubMed

13.

Sebo TJ et al (2000) The percent of cores positive for cancer in prostate needle biopsy specimens is strongly predictive of tumor stage and volume at radical prostatectomy. J Urol 163(1):174–178CrossRefPubMed

14.

Singh H et al (2004) Six additional systematic lateral cores enhance sextant biopsy prediction of pathological features at radical prostatectomy. J Urol 171(1):204–209CrossRefPubMed

15.

Stamey TA (1995) Making the most out of six systematic sextant biopsies. Urology 45(1):2–12CrossRefPubMed

16.

de la Taille A et al (2003) Prospective evaluation of a 21-sample needle biopsy procedure designed to improve the prostate cancer detection rate. Urology 61(6):1181–1186CrossRefPubMed

17.

Touijer K, Guillonneau B (2006) Laparoscopic radical prostatectomy: a critical analysis of surgical quality. Eur Urol 49(4):625–632CrossRefPubMed

Title: Saturation biopsy protocol enhances prediction of pT3 and surgical margin status on prostatectomy specimen
Authors: Aurélien Descazeaud
Mark Rubin
Stéphanie Chemama
Stéphane Larré
Laurent Salomon
Yves Allory
Dimitri Vordos
Andras Hoznek
René Yiou
Dominique Chopin
Claude Abbou
Alexandre de la Taille
Publication date: 01-12-2006
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 6/2006
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-006-0134-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Saturation biopsy protocol enhances prediction of pT3 and surgical margin status on prostatectomy specimen

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2006

Complications of endoscopic extraperitoneal radical prostatectomy (EERPE): prevention and management

Retarded ejaculation

Understanding the needs and objectives of erectile dysfunction patients

Adverse effects of drug therapies on male and female sexual function

Significance of hypogonadism in erectile dysfunction

Female sexual dysfunction, voiding symptoms and depression: common findings in partners of men with erectile dysfunction