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Journal of Assisted Reproduction and Genetics

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01-11-2020 | SARS-CoV-2 | Reproductive Physiology and Disease

SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts

Authors: Wafaa Essahib, Greta Verheyen, Herman Tournaye, Hilde Van de Velde

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2020

Abstract

Purpose

To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts.

Methods

Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research.

Results

SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma.

Conclusion

Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.

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Title: SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
Authors: Wafaa Essahib
Greta Verheyen
Herman Tournaye
Hilde Van de Velde
Publication date: 01-11-2020
Publisher: Springer US
Keyword: SARS-CoV-2
Published in: Journal of Assisted Reproduction and Genetics / Issue 11/2020
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-020-01952-x

At a glance: The STEP trials

Springer Medicine

SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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