Published in:
01-12-2021 | SARS-CoV-2 | Research Letter
Causes and timing of death in critically ill COVID-19 patients
Authors:
Damien Contou, Radj Cally, Florence Sarfati, Paul Desaint, Megan Fraissé, Gaëtan Plantefève
Published in:
Critical Care
|
Issue 1/2021
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Excerpt
Mortality rate of critically ill COVID-19 patients is high, especially in those requiring invasive mechanical ventilation. However, the causes and the timing of death of patients admitted to the ICU for SARS-CoV-2 pneumonia have been poorly reported [
1,
2]. Whether patients mainly die from refractory respiratory failure directly due to SARS-CoV-2 pneumonia or from sepsis as reported in non-COVID-19 ARDS patients [
3] is unknown. Moreover, the increased risk of pulmonary embolism extensively described among COVID-19 patients together with the SARS-CoV-2-associated myocardial injuries [
4] may expose critically ill COVID-19 patients to death from a cardiac origin [
5]. Additionally, the increased intensity of thromboprophylaxis commonly used to prevent thrombotic events might also promote fatal hemorrhagic events. …