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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | SARS-CoV-2 | Research

Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19

Authors: Kentaro Wakamatsu, Zenzo Nagasawa, Kouta Katsuki, Hiroyuki Kumazoe, Masayo Yasuda, Sae Kawamoto, Ayano Kawamura, Tsuyoshi Ueno, Ruriko Kiyotani, Izumi Fukui, Sanae Maki, Nobuhiko Nagata, Masayuki Kawasaki, Hozumi Yamada

Published in: European Journal of Medical Research | Issue 1/2023

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Abstract

Background

Pathogenic genetic testing for coronavirus disease 2019 (COVID-19) can detect viruses with high sensitivity; however, there are several challenges. In the prevention, testing, and treatment of COVID-19, more effective, safer, and convenient methods are desired. We evaluated the possibility of monocyte distribution width (MDW) as an infection biomarker in COVID-19 testing.

Methods

The efficacy of MDW as a screening test for COVID-19 was retrospectively assessed in 80 patients in the COVID-19 group and 232 patients in the non-COVID-19 group (141 patients with acute respiratory infection, 19 patients with nonrespiratory infection, one patient with a viral infection, 11 patients who had received treatment for COVID-19, one patient in contact with COVID-19 patients, and 59 patients with noninfectious disease).

Results

The median MDW in 80 patients in the COVID-19 group was 23.3 (17.2–33.6), and the median MDW in 232 patients in the non-COVID-19 group was 19.0 (13.6–30.2) (P < 0.001). When the COVID-19 group was identified using the MDW cut-off value of 21.3 from the non-COVID-19 group, the area under the curve (AUC) was 0.844, and the sensitivity and specificity were 81.3% and 78.2%, respectively. Comparison of MDW by severity between the COVID-19 group and patients with acute respiratory infection in the non-COVID-19 group showed that MDW was significantly higher in the COVID-19 group for all mild, moderate I, and moderate II disease.

Conclusions

MDW (cut-off value: 21.3) may be used as a screening test for COVID-19 in fever outpatients.
Trial registration This study was conducted after being approved by the ethics committee of National Hospital Organization Omuta National Hospital (Approval No. 3-19). This study can be accessed via https://​omuta.​hosp.​go.​jp/​files/​000179721.​pdf.
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Metadata
Title
Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19
Authors
Kentaro Wakamatsu
Zenzo Nagasawa
Kouta Katsuki
Hiroyuki Kumazoe
Masayo Yasuda
Sae Kawamoto
Ayano Kawamura
Tsuyoshi Ueno
Ruriko Kiyotani
Izumi Fukui
Sanae Maki
Nobuhiko Nagata
Masayuki Kawasaki
Hozumi Yamada
Publication date
01-12-2023
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01086-7

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