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Open Access 01-12-2021 | SARS-CoV-2 | Study protocol

Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19)

Authors: Anna Suy, Itziar Garcia-Ruiz, Melchor Carbonell, Pablo Garcia-Manau, Carlota Rodo, Nerea Maiz, Elena Sulleiro, Andres Anton, Juliana Esperalba, Nuria Fernández-Hidalgo, Marie Antoinette Frick, Fatima Camba, Tomas Pumarola, Elena Carreras, On behalf of the Gesta-COVID19 Collaboration Group

Published in: BMC Pregnancy and Childbirth | Issue 1/2021

Abstract

Background

The Coronavirus Disease 2019 (COVID-19) is a novel disease which has been having a worldwide affect since December 2019. Evidence regarding the effects of SARS-CoV-2 during pregnancy is conflicting. The presence of SARS-CoV-2 has been demonstrated in biological samples during pregnancy (placenta, umbilical cord or amniotic fluid); however, maternal and fetal effects of the virus are not well known.

Methods

Descriptive, multicentre, longitudinal, observational study in eight tertiary care hospitals throughout Spain, that are referral centres for pregnant women with COVID-19. All pregnant women with positive SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction during their pregnancy or 14 days preconception and newborns born to mothers infected with SARS-CoV-2 will be included. They will continue to be followed up until 4 weeks after delivery. The aim of the study is to investigate both the effect of COVID-19 on the pregnancy, and the effect of the pregnancy status with the evolution of the SARS-CoV-2 disease. Other samples (faeces, urine, serum, amniotic fluid, cord and peripheral blood, placenta and breastmilk) will be collected in order to analyse whether or not there is a risk of vertical transmission and to describe the behaviour of the virus in other fluids. Neonates will be followed until 6 months after delivery to establish the rate of neonatal transmission. We aim to include 150 pregnant women and their babies. Ethics approval will be obtained from all the participating centres.

Discussion

There is little information known about COVID-19 and its unknown effects on pregnancy. This study will collect a large number of samples in pregnant women which will allow us to demonstrate the behaviour of the virus in pregnancy and postpartum in a representative cohort of the Spanish population.

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Title: Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19)
Authors: Anna Suy
Itziar Garcia-Ruiz
Melchor Carbonell
Pablo Garcia-Manau
Carlota Rodo
Nerea Maiz
Elena Sulleiro
Andres Anton
Juliana Esperalba
Nuria Fernández-Hidalgo
Marie Antoinette Frick
Fatima Camba
Tomas Pumarola
Elena Carreras
On behalf of the Gesta-COVID19 Collaboration Group
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: SARS-CoV-2
COVID-19
Published in: BMC Pregnancy and Childbirth / Issue 1/2021
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-021-03572-4

2024 ASCO Annual Meeting

Springer Medicine

Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19)

Abstract

Background

Methods

Discussion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Discussion

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