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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | SARS-CoV-2 | Letter

Assessment of pulmonary surfactant in COVID-19 patients

Authors: Peter Schousboe, Lothar Wiese, Christian Heiring, Henrik Verder, Porntiva Poorisrisak, Povl Verder, Henning Bay Nielsen

Published in: Critical Care | Issue 1/2020

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Excerpt

The clinical presentation of coronavirus 2 (SARS-CoV-2) ranges from asymptomatic to severe respiratory failure, and correspondingly requirement for respiratory support ranging from varying levels of supplementary O2, to non-invasive and invasive ventilation. In a recent editorial by Gattinoni et al. [1], it is proposed that, based on different pathophysiology need for ventilator support, there are two groups of COVID-19 patients: one group that develops acute respiratory distress syndrome (ARDS) with low compliance, and another classified as non-ARDS with normal compliance and hypoxemia caused by a high level of intrapulmonary shunting. Furthermore, non-ARDS type COVID-19 pneumonia may transit to ARDS-type COVID-19 by self-inflicted or ventilator-induced lung injury. …
Literature
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Gattinoni L, Chiumello D, Rossi S. COVID-19 pneumonia: ARDS or not? Crit Care. 2020;24(1):154.CrossRef
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Nieman GF, Andrews P, Satalin J, Wilcox K, Kollisch-Singule M, Madden M, Aiash H, Blair SJ, Gatto LA, Habashi NM. Acute lung injury: how to stabilize a broken lung. Crit Care. 2018;22(1):136.CrossRef
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Walmrath D, Günther A, Ghofrani HA, Schermuly R, Schneider T, Grimminger F, Seeger W. Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis. Am J Crit Care Med. 1996;154(1):57–62.CrossRef
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Kamlin O, Bradley M: Multicentre randomised controlled trial of surfactant plus budesonide to improve survival free of bronchopulmonary dysplasia in extremely preterm infants PLUSS trial. Australian New Zealand Clinical Trials Registry; ACTRN12617000322​336.
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Heiring C, Verder H, Schousboe P, Jessen TE, Bender L, Ebbesen F, Dahl M, Eschen C, Fenger-Grøn J, Höskuldsson A, Matthews M, Reinholdt J, Scoutaris N, Smedegaard H. Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates: 2. Clinical part. Acta Paediatr. 2020;109(2):285–90.CrossRef
Metadata
Title
Assessment of pulmonary surfactant in COVID-19 patients
Authors
Peter Schousboe
Lothar Wiese
Christian Heiring
Henrik Verder
Porntiva Poorisrisak
Povl Verder
Henning Bay Nielsen
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03268-9

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