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European Spine Journal

11-05-2024 | Sarcopenia | Original Article

Causal associations between sarcopenia-related traits and intervertebral disc degeneration: a two-sample mendelian randomization analysis

Authors: Weihui Qi, Zhenglin Mei, Xinning Mao, Li Zhu, Yinyan Shao, Guofen Ge, Wei Zhang, Hao Pan, Dong Wang

Published in: European Spine Journal

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Abstract

Background

Sarcopenia (SP) and intervertebral disc degeneration (IVDD) have a higher incidence in the elderly population. Previous studies have indicated a potential association between SP and IVDD. The objective of this study is to elucidate the potential causal relationship between sarcopenia-related traits and IVDD through Two-sample Mendelian randomization (MR) analysis.

Methods

We utilized a genome-wide association study conducted on the European population to collect aggregated data on sarcopenia and IVDD. Inverse variance weighting was primarily employed, supplemented by MR Egger, weighted median, simple model, and weighted model methods. Additionally, sensitivity analysis was performed to assess the robustness of the findings.

Results

Appendicular lean mass is positively associated with “Other intervertebral disc disorders” (OIDD) and “Prolapsed or slipped disc” (POSD) (OIDD: p = 0.002, OR = 1.120; POSD: p < 0.001, OR = 1.003), while grip strength (GS) is positively associated with POSD (left: p = 0.004, OR = 1.008; right: p < 0.001, OR = 1.010). It is worth mentioning that walking pace has significant causal relationship with “Low back pain” (LBP), “Lower back pain or/and sciatica” (LBPOAS), “Sciatica with lumbago” (SWL) and OIDD (LBP: p < 0.001, OR = 0.204; LBPOAS: p < 0.001, OR = 0.278; SWL: p = 0.003, OR = 0.249; OIDD: p < 0.001, OR = 0.256).

Conclusion

The present study revealed the causal relationship between SP-related traits and IVDD and recommended to prevent and treat sarcopenia as a means of preventing IVDD in clinic practice.
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Literature
1.
2.
Patel HP et al (2013) Prevalence of sarcopenia in community-dwelling older people in the UK using the European working group on sarcopenia in older people (EWGSOP) definition: findings from the Hertfordshire cohort Study (HCS). Age Ageing 42(3):378–384CrossRefPubMedPubMedCentral
3.
Beard JR et al (2016) The World report on ageing and health: a policy framework for healthy ageing. Lancet (London, England) 387(10033):2145–2154CrossRefPubMed
4.
Janssen I et al (2004) The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 52(1):80–85CrossRefPubMed
5.
Cruz-Jentoft AJ et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(1):16–31CrossRefPubMed
6.
7.
8.
Liu C et al (2022) Osteoporosis and sarcopenia-related traits: a bi-directional mendelian randomization study. Front Endocrinol 13:975647CrossRef
9.
Jones SE et al (2015) Sarcopenia in COPD: prevalence, clinical correlates and response to pulmonary rehabilitation. Thorax 70(3):213–218CrossRefPubMed
10.
Chen LK et al (2014) Sarcopenia in Asia: consensus report of the Asian working group for sarcopenia. J Am Med Dir Assoc 15(2):95–101CrossRefPubMed
11.
Cruz-Jentoft AJ et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the european working group on sarcopenia in older people. Age Ageing 39(4):412–423CrossRefPubMedPubMedCentral
12.
Yang S et al (2020) Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen. Ageing Res Rev 57:100978CrossRefPubMed
13.
Kherad M et al (2017) Risk factors for low back pain and sciatica in elderly men-the MrOS Sweden study. Age Ageing 46(1):64–71PubMed
14.
James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, Abdollahpour I (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet (London, England) 392(10159):1789–1858CrossRef
15.
16.
Misra D et al (2019) Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia. Arthritis Rheumatol (Hoboken, N.J.) 71(2):232–237CrossRef
17.
Kim WJ et al (2021) Sarcopenia and back muscle degeneration as risk factors for degenerative adult spinal deformity with sagittal imbalance and degenerative spinal disease: a comparative study. World Neurosurg 148:e547–e555CrossRefPubMed
18.
Tanaka Y et al (2023) Muscle strength rather than appendicular skeletal muscle mass might affect spinal sagittal alignment, low back pain, and health-related quality of life. Sci Rep 13(1):9894CrossRefPubMedPubMedCentral
19.
Skrivankova VW et al (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement. JAMA 326(16):1614–1621CrossRefPubMed
20.
Davies NM, Holmes MV, Davey Smith G (2018) Reading mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ (Clinical Research ed.) 362:k601CrossRefPubMed
21.
Smith GD, Ebrahim S (2003) Mendelian randomization: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32(1):22
22.
Skrivankova VW et al (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ (Clinical Research ed) 375:n2233PubMed
23.
Pei Y-F et al (2020) The genetic architecture of appendicular lean mass characterized by association analysis in the UK biobank study. Commun Biol 3(1):608CrossRefPubMedPubMedCentral
24.
Verbanck M et al (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet 50(5):693–698CrossRefPubMedPubMedCentral
25.
Ong J-S, MacGregor S (2019) Implementing MR-PRESSO and GCTA-GSMR for pleiotropy assessment in mendelian randomization studies from a practitioner’s perspective. Genet Epidemiol 43(6):609–616CrossRefPubMedPubMedCentral
26.
27.
28.
Sions JM et al (2017) Trunk muscle characteristics of the multifidi, erector spinae, psoas, and quadratus lumborum in older adults with and without chronic low back pain. J Orthop Sports Phys Ther 47(3):173–179CrossRefPubMedPubMedCentral
29.
30.
Park MW, Park SJ, Chung SG (2023) relationships between skeletal muscle mass, lumbar lordosis, and chronic low back pain in the elderly. Neurospine 20(3):959–968CrossRefPubMedPubMedCentral
31.
Quint U et al (1998) Importance of the intersegmental trunk muscles for the stability of the lumbar spine. biomech Study Vitro Spine 23(18):1937–1945
32.
Kang S et al (2021) The effects of paraspinal muscle volume on physiological load on the lumbar vertebral column: a finite-element study. Spine 46(19):E1015–E1021CrossRefPubMed
33.
34.
35.
Studenski SA et al (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol Ser A Biol Sci Med Sci 69(5):547–558CrossRef
36.
Long G et al (2021) Hand grip strength as a predictor of recovery from low back pain in the pregnant women-a prospective study. J Orthop Sci Off J Jpn Orthop Assoc 26(4):566–571
37.
Faber A et al (2012) Does muscle strength predict future musculoskeletal disorders and sickness absence? Occup Med (Oxford, England) 62(1):41–46CrossRef
38.
Felício DC et al (2017) Handgrip strength is associated with, but poorly predicts, disability in older women with acute low back pain: a 12-month follow-up study. Maturitas 104:19–23CrossRefPubMed
39.
Hansen L et al (2006) Anatomy and biomechanics of the back muscles in the lumbar spine with reference to biomechanical modeling. Spine 31(17):1888–1899CrossRefPubMed
40.
Distefano G, Goodpaster BH (2018) Effects of exercise and aging on skeletal muscle. Cold Spring Harbor Perspect Med 8(3):a029785CrossRef
41.
42.
Cesari M et al (2009) Added value of physical performance measures in predicting adverse health-related events: results from the health, aging and body composition study. J Am Geriatr Soc 57(2):251–259CrossRefPubMedPubMedCentral
Metadata
Title
Causal associations between sarcopenia-related traits and intervertebral disc degeneration: a two-sample mendelian randomization analysis
Authors
Weihui Qi
Zhenglin Mei
Xinning Mao
Li Zhu
Yinyan Shao
Guofen Ge
Wei Zhang
Hao Pan
Dong Wang
Publication date
11-05-2024
Publisher
Springer Berlin Heidelberg
Published in
European Spine Journal
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-024-08291-w