Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Geriatrics
Published in: BMC Geriatrics 1/2022

Open Access 01-12-2022 | Sarcopenia | Research

Association between oral intake magnesium and sarcopenia: a cross-sectional study

Authors: Shih-Wei Yang, Yuan-Yuei Chen, Wei-Liang Chen

Published in: BMC Geriatrics | Issue 1/2022

Login to get access

Abstract

Background

Sarcopenia is a common skeletal muscle disorder in the elderly population. The patients with sarcopenia increased the cost of care and the risk for hospitalization. Magnesium deficiency might increase reactive oxygen species and protein damage. The purpose of our study was to demonstrate the relation between oral intake magnesium and sarcopenia by European Working Group on Sarcopenia in Older People (EWGSOP) 2 definition.

Methods

Our study included 2532 participants with 1310 males and 1222 females. The multiple logistic regression model was designed to test the cross-sectional protective outcome of oral intake magnesium for sarcopenia.

Results

Oral intake magnesium had a protective outcome with sarcopenia (odd ratio (OR) = 0.997, 95% CI = 0.996, 0.998, P < 0.001). After fully adjusted, the significance persisted with OR = 0.998 (95% CI = 0.996, 0.999, P < 0.001).

Conclusion

Results of the present study showed the dose dependent relationship between oral intake magnesium and sarcopenia. Sufficient oral intake magnesium might prevent patient from sarcopenia.
Appendix
Available only for authorised users
Literature
1.
Bauer J, Morley JE, Schols A, Ferrucci L, Cruz-Jentoft AJ, Dent E, et al. Sarcopenia: a time for action. An SCWD Position Paper J Cachexia Sarcopenia Muscle. 2019;10(5):956–61.CrossRef
2.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31.CrossRef
3.
Santilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):177–80.PubMedPubMedCentral
4.
Sousa AS, Guerra RS, Fonseca I, Pichel F, Ferreira S, Amaral TF. Financial impact of sarcopenia on hospitalization costs. Eur J Clin Nutr. 2016;70(9):1046–51.CrossRef
5.
Dodds RM, Roberts HC, Cooper C, Sayer AA. The epidemiology of sarcopenia. J Clin Densitom. 2015;18(4):461–6.CrossRef
6.
Bloom I, Shand C, Cooper C, Robinson S, Baird J. Diet quality and sarcopenia in older adults: a systematic review. Nutrients. 2018;10(3).
7.
de Sire A, Ferrillo M, Lippi L, Agostini F, de Sire R, Ferrara PE, et al. Sarcopenic dysphagia, malnutrition, and Oral frailty in elderly: a comprehensive review. Nutrients. 2022;14(5).
8.
Avola M, Mangano GRA, Testa G, Mangano S, Vescio A, Pavone V, et al. Rehabilitation strategies for patients with femoral neck fractures in sarcopenia: a narrative review. J Clin Med. 2020;9(10).
9.
Robinson S, Cooper C, Aihie SA. Nutrition and sarcopenia: a review of the evidence and implications for preventive strategies. J Aging Res. 2012;2012:510801.CrossRef
10.
Wolfe RR, Miller SL, Miller KB. Optimal protein intake in the elderly. Clin Nutr. 2008;27(5):675–84.CrossRef
11.
Calder PC. N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83(6 Suppl):1505s–19s.CrossRef
12.
13.
Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, et al. Oxidative stress and severe walking disability among older women. Am J Med. 2007;120(12):1084–9.CrossRef
14.
Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7(9):8199–226.CrossRef
15.
Van Laecke S. Hypomagnesemia and hypermagnesemia. Acta Clin Belg. 2019;74(1):41–7.CrossRef
16.
de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1–46.CrossRef
17.
Gragossian A, Bashir K, Friede R. Hypomagnesemia. In: StatPearls. Treasure Island. FL: StatPearls Publishing; 2022.
18.
Rock E, Astier C, Lab C, Vignon X, Gueux E, Motta C, et al. Dietary magnesium deficiency in rats enhances free radical production in skeletal muscle. J Nutr. 1995;125(5):1205–10.PubMed
19.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing. 2010;39(4):412–23.CrossRef
20.
Dhillon RJ, Hasni S. Pathogenesis and Management of Sarcopenia. Clin Geriatr Med. 2017;33(1):17–26.CrossRef
21.
Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, et al. Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol. 2013;45(10):2288–301.CrossRef
22.
Rodríguez-Zavala JS, Moreno-Sánchez R. Modulation of oxidative phosphorylation by Mg2+ in rat heart mitochondria. J Biol Chem. 1998;273(14):7850–5.CrossRef
23.
Kramer JH, Misík V, Weglicki WB. Magnesium-deficiency potentiates free radical production associated with postischemic injury to rat hearts: vitamin E affords protection. Free Radic Biol Med. 1994;16(6):713–23.CrossRef
24.
Shah NC, Liu JP, Iqbal J, Hussain M, Jiang XC, Li Z, et al. Mg deficiency results in modulation of serum lipids, glutathione, and NO synthase isozyme activation in cardiovascular tissues: relevance to de novo synthesis of ceramide, serum mg and atherogenesis. Int J Clin Exp Med. 2011;4(2):103–18.PubMedPubMedCentral
25.
Liu M, Jeong EM, Liu H, Xie A, So EY, Shi G, et al. Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function. JCI insight. 2019;4(1).
26.
Rubin H. Intracellular free mg (2+) and MgATP (2-) in coordinate control of protein synthesis and cell proliferation. In: Vink R, Adelaide NM, editors. Magnesium in the central nervous system. AU: University of Adelaide Press; 2011.
27.
Richardson CJ, Schalm SS, Blenis J. PI3-kinase and TOR: PIKTORing cell growth. Semin Cell Dev Biol. 2004;15(2):147–59.CrossRef
28.
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103(2):253–62.CrossRef
29.
Rubin H. Central roles of Mg2+ and MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformation. Adv Cancer Res. 2005;93:1–58.CrossRef
30.
King DE, Mainous AG 3rd, Geesey ME, Ellis T. Magnesium intake and serum C-reactive protein levels in children. Magnes Res. 2007;20(1):32–6.PubMed
31.
King D, Mainous A, Geesey M, Egan B, Rehman S. Magnesium supplement intake and C-reactive protein levels in adults. Nutr Res. 2006;26.
32.
Chacko SA, Song Y, Nathan L, Tinker L, de Boer IH, Tylavsky F, et al. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care. 2010;33(2):304–10.CrossRef
Metadata
Title
Association between oral intake magnesium and sarcopenia: a cross-sectional study
Authors
Shih-Wei Yang
Yuan-Yuei Chen
Wei-Liang Chen
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Sarcopenia
Published in
BMC Geriatrics / Issue 1/2022
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-022-03522-5

Other articles of this Issue 1/2022

BMC Geriatrics 1/2022 Go to the issue

Research

Association of high body mass index, waist circumference, and body fat percentage with sarcopenia in older women

Research

Effects of computer-aided rowing exercise systems on improving muscle strength and function in older adults with mild knee osteoarthritis: a randomized controlled clinical trial

Research

Performance of the APOP-screener for predicting in-hospital mortality in older COVID-19 patients: a retrospective study

Research

Stakeholders’ perspectives of mobile x-ray services in support of healthcare-in-place in residential aged care facilities: a qualitative study

Research

The effectiveness of interventions to reduce adverse outcomes among older adults following Emergency Department discharge: umbrella review

Research article

Prognostic value of estimated glomerular filtration rate in hospitalised older patients (over 65) with COVID-19: a multicentre, European, observational cohort study
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits