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01-02-2015 | Thoracic Oncology

Salvage Lymphadenectomy Versus Salvage Radiotherapy/Chemoradiotherapy for Recurrence in Cervical Lymph Node After Curative Resection of Esophageal Squamous Cell Carcinoma

Authors: Xiao Ma, MD, Kuaile Zhao, MD, Wei Guo, MD, Su Yang, MD, Xiaoli Zhu, MD, Jiaqing Xiang, MD, Yawei Zhang, MD, Hecheng Li, MD

Published in: Annals of Surgical Oncology | Issue 2/2015

Abstract

Background

A consensus treatment strategy for patients with esophageal squamous cell carcinoma (ESCC) that recurs after definitive esophagectomy has not been established. This study compared outcomes in ESCC patients who underwent salvage lymphadenectomy and those who underwent salvage radiotherapy/chemoradiotherapy for recurrence in cervical lymph nodes.

Methods

Clinical characteristics of 79 patients were analyzed. Overall survival was calculated from the day of salvage treatment to the time of death or last follow-up. Survival rates were estimated using the Kaplan–Meier method, and statistical analysis was performed using the log-rank test for equality of the survival curves. The χ ² test was used to compare patient and tumor characteristics. Univariate analysis was performed using the log-rank test, and multivariate analysis was performed using the Cox proportional hazards model.

Results

Initial treatment against recurrence (salvage lymphadenectomy vs. salvage radiotherapy or chemoradiotherapy) was the only significant prognostic factor with a hazard ratio of 2.358 and 95 % confidence interval of 1.067–5.210. Survival curves were significantly different between patients receiving salvage surgery and those receiving salvage radiotherapy/chemoradiotherapy (p = 0.0269).

Conclusions

Compared with salvage radiotherapy/radiochemotherapy, salvage cervical lymphadenectomy might be the main treatment for esophageal carcinoma patients who developed cervical lymph node recurrence after curative esophagectomy.

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Title: Salvage Lymphadenectomy Versus Salvage Radiotherapy/Chemoradiotherapy for Recurrence in Cervical Lymph Node After Curative Resection of Esophageal Squamous Cell Carcinoma
Authors: Xiao Ma, MD
Kuaile Zhao, MD
Wei Guo, MD
Su Yang, MD
Xiaoli Zhu, MD
Jiaqing Xiang, MD
Yawei Zhang, MD
Hecheng Li, MD
Publication date: 01-02-2015
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 2/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-014-4008-8

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Salvage Lymphadenectomy Versus Salvage Radiotherapy/Chemoradiotherapy for Recurrence in Cervical Lymph Node After Curative Resection of Esophageal Squamous Cell Carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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