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01-06-2003 | Short Communication

Salivary Flow Rates and Pharmacokinetics in Healthy Japanese and Caucasian Volunteers Administered Oral Pilocarpine

A Comparative Study

Authors: Dr Richard Wasnich, Susan Gallagher, Stacy Stanek, John R. MacDonald, Guhan Balan, Yasuhiro Omori, Imao Mikoshiba

Published in: Clinical Drug Investigation | Issue 6/2003

Excerpt

Salivary insufficiency and the resultant xerostomia are consequences of tissue damage from radiotherapy used in the management of head and neck cancer[1,2]and from Sjögren’s syndrome, an autoimmune disease in which lymphocytic infiltrates destroy moisture-producing exocrine glands.[3]Consequences of xerostomia include oral discomfort, difficulty in eating and swallowing solid food and speaking without the additional aid of water, problems with phonation, and detrimental effects to the oral cavity, including dental caries and tooth loss as well as difficulty in wearing dentures. These events result in a significant decrease in quality of life and marked impairment in the activities of daily living for these patients. …

¹ The use of tradenames is for product identification only and does not imply endorsement.

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Title: Salivary Flow Rates and Pharmacokinetics in Healthy Japanese and Caucasian Volunteers Administered Oral Pilocarpine
A Comparative Study
Authors: Dr Richard Wasnich
Susan Gallagher
Stacy Stanek
John R. MacDonald
Guhan Balan
Yasuhiro Omori
Imao Mikoshiba
Publication date: 01-06-2003
Publisher: Springer International Publishing
Published in: Clinical Drug Investigation / Issue 6/2003
Print ISSN: 1173-2563
Electronic ISSN: 1179-1918
DOI: https://doi.org/10.2165/00044011-200323060-00005

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Salivary Flow Rates and Pharmacokinetics in Healthy Japanese and Caucasian Volunteers Administered Oral Pilocarpine

A Comparative Study

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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