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01-06-2012 | Original Article

Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

Authors: Laura Tarkkila, Jussi Furuholm, Aila Tiitinen, Jukka H. Meurman

Published in: Clinical Oral Investigations | Issue 3/2012

Abstract

This study aims to investigate salivary flow and biochemical constituents of menopausal-age women with the hypothesis that women using hormone therapy (HT) might present better saliva values than non-users. Two hundred HT users and 200 non-users were selected at random from a cohort study of 3,173 peri- and postmenopausal women and invited to a 2-year clinical follow-up study. Clinical examination with saliva sampling was made at baseline and 2 years later. Salivary total protein, albumin, and immunoglobulin (Ig) concentrations were analyzed. Final material included 106 consistent HT users and 55 non-users. Backward logistic regression analysis was made to determine the risk factors for higher or lower than medium salivary protein values. No difference was seen in salivary flow rate, total protein, and IgA values between baseline and follow-up measurements or between the groups. Albumin, IgG, and IgM concentrations were significantly lower in the 2-year samples of the HT group when compared with baseline. IgA and IgM values were higher in the non-HT 2-year samples when compared with the corresponding HT samples. The only significant explanatory factor for higher than median salivary albumin concentration was the number of teeth both at baseline and 2 years later. HT possibly improved epithelial integrity since the concentrations of serum components albumin, IgG, and IgM decreased during the follow-up. HT as such does not seem to affect saliva, although it may modify it. The clinical relevance of these results needs to be assessed in future studies.

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Title: Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study
Authors: Laura Tarkkila
Jussi Furuholm
Aila Tiitinen
Jukka H. Meurman
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 3/2012
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-011-0573-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Saliva in perimenopausal and early postmenopausal women. A 2-year follow-up study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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