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Published in: Annals of General Psychiatry 1/2011

Open Access 01-12-2011 | Primary research

Sales of antidepressants, suicides and hospital admissions for depression in Veneto Region, Italy, from 2000 to 2005: an ecological study

Authors: Giuseppe Guaiana, Margherita Andretta, Eric Griez, Bruno Biancosino, Luigi Grassi

Published in: Annals of General Psychiatry | Issue 1/2011

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Abstract

Background

Increased prescription of antidepressants has been consistently associated with a decrease in suicide rates in several countries. The aim of this study is to explore antidepressant consumption, suicide rates and admission for depression in the Veneto Region, Italy, in order to see whether the same pattern could be detected.

Methods

Data from the Italian Ministry of Health (admissions for depression), the Pharmacy Service of a Local Health Unit (antidepressant prescribing) and from the Epidemiological System of the Veneto region (suicide rates) were collected from 2000 to 2005 for the Veneto region.

Results

Suicide rates did not show any marked increase but were stable in males and females. Antidepressant prescribing increased exponentially over the period examined, whilst admissions for depression markedly decreased. The trend for an exponential increase in antidepressant prescribing in the Veneto region is shared with other countries and locales.

Conclusions

It is possible that the increase in antidepressant prescribing might be associated with earlier treatment of depression, thus decreasing the likelihood of aggravation of depression.
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Literature
1.
go back to reference Isacsson G, Rich C: Antidepressant medication prevents suicide: a review of ecological studies. Eur Psychiatr Rev. 2008, 1: 24-26. Isacsson G, Rich C: Antidepressant medication prevents suicide: a review of ecological studies. Eur Psychiatr Rev. 2008, 1: 24-26.
2.
go back to reference Guaiana G, Andretta M, Corbari L, Mirandola M, Sorio A, D'Avanzo B, Barbui C: Antidepressant drug consumption and public health indicators in Italy 1955 to 2000. J Clin Psychiatry. 2005, 66: 750-755. 10.4088/JCP.v66n0612.CrossRefPubMed Guaiana G, Andretta M, Corbari L, Mirandola M, Sorio A, D'Avanzo B, Barbui C: Antidepressant drug consumption and public health indicators in Italy 1955 to 2000. J Clin Psychiatry. 2005, 66: 750-755. 10.4088/JCP.v66n0612.CrossRefPubMed
3.
go back to reference Rich CL, Isacsson G: Suicide and antidepressants in south Alabama: evidence for improved treatment of depression. J Affect Disord. 1997, 45: 135-142. 10.1016/S0165-0327(97)00067-0.CrossRefPubMed Rich CL, Isacsson G: Suicide and antidepressants in south Alabama: evidence for improved treatment of depression. J Affect Disord. 1997, 45: 135-142. 10.1016/S0165-0327(97)00067-0.CrossRefPubMed
4.
go back to reference Healy D, Aldred G: Antidepressant drug use and the risk of suicide. Int Rev Psychiatry. 2005, 17: 163-172. 10.1080/09540260500071624.CrossRefPubMed Healy D, Aldred G: Antidepressant drug use and the risk of suicide. Int Rev Psychiatry. 2005, 17: 163-172. 10.1080/09540260500071624.CrossRefPubMed
5.
go back to reference Isacsson G, Rich C, Jureidin J, Raven M: The increased use of antidepressants has contributed to the worldwide reduction in suicide rates. Br J Psychiatry. 2010, 196: 429-433. 10.1192/bjp.bp.109.076166.CrossRefPubMed Isacsson G, Rich C, Jureidin J, Raven M: The increased use of antidepressants has contributed to the worldwide reduction in suicide rates. Br J Psychiatry. 2010, 196: 429-433. 10.1192/bjp.bp.109.076166.CrossRefPubMed
6.
go back to reference Isacsson G, Bergman U, Rich C: Antidepressant depression and suicide: an analysis of the San Diego study. J Affect Disord. 1994, 32: 277-286. 10.1016/0165-0327(94)90092-2.CrossRefPubMed Isacsson G, Bergman U, Rich C: Antidepressant depression and suicide: an analysis of the San Diego study. J Affect Disord. 1994, 32: 277-286. 10.1016/0165-0327(94)90092-2.CrossRefPubMed
7.
go back to reference Barbui C, Esposito E, Cipriani A: Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies. CMAJ. 2009, 180: 291-297. 10.1503/cmaj.081514.PubMedCentralCrossRefPubMed Barbui C, Esposito E, Cipriani A: Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies. CMAJ. 2009, 180: 291-297. 10.1503/cmaj.081514.PubMedCentralCrossRefPubMed
8.
go back to reference Vyssoki B, Willeit M, Blüml V, Höfer P, Erfurth A, Psota G, Lesch OM, Kapusta ND: Inpatient treatment of major depression in Austria between 1989 and 2009: Impact of downsizing of psychiatric hospitals on admissions, suicide rates and outpatient psychiatric services. J Affect Disord. 2011, 133: 93-96. 10.1016/j.jad.2011.03.031.CrossRefPubMed Vyssoki B, Willeit M, Blüml V, Höfer P, Erfurth A, Psota G, Lesch OM, Kapusta ND: Inpatient treatment of major depression in Austria between 1989 and 2009: Impact of downsizing of psychiatric hospitals on admissions, suicide rates and outpatient psychiatric services. J Affect Disord. 2011, 133: 93-96. 10.1016/j.jad.2011.03.031.CrossRefPubMed
9.
go back to reference Roy AC: Depressed patients who suicide at their first attempt have had few admissions. Depress Anxiety. 1999, 9: 75-77. 10.1002/(SICI)1520-6394(1999)9:2<75::AID-DA5>3.0.CO;2-D.CrossRefPubMed Roy AC: Depressed patients who suicide at their first attempt have had few admissions. Depress Anxiety. 1999, 9: 75-77. 10.1002/(SICI)1520-6394(1999)9:2<75::AID-DA5>3.0.CO;2-D.CrossRefPubMed
10.
go back to reference Goldberg JF, Harrow M, Whiteside JE: Risk for bipolar illness in patients initially hospitalized for unipolar depression. Am J Psychiatry. 2001, 158: 1265-1270. 10.1176/appi.ajp.158.8.1265.CrossRefPubMed Goldberg JF, Harrow M, Whiteside JE: Risk for bipolar illness in patients initially hospitalized for unipolar depression. Am J Psychiatry. 2001, 158: 1265-1270. 10.1176/appi.ajp.158.8.1265.CrossRefPubMed
11.
go back to reference Pope GC, Ellis RP, Ash AS, Liu CF, Ayanian JZ, Bates DW, Burstin H, Iezzoni LI, Ingber MJ: Principal Inpatient Diagnostic Cost Group Model for Medicare Risk Adjustment. Health Care Financ Rev. 2000, 3: 93-118. Pope GC, Ellis RP, Ash AS, Liu CF, Ayanian JZ, Bates DW, Burstin H, Iezzoni LI, Ingber MJ: Principal Inpatient Diagnostic Cost Group Model for Medicare Risk Adjustment. Health Care Financ Rev. 2000, 3: 93-118.
13.
go back to reference Hardy P: Severe depression: morbidity-mortality and suicide. Encephale. 2009, 35 (Suppl 7): S269-S271.CrossRefPubMed Hardy P: Severe depression: morbidity-mortality and suicide. Encephale. 2009, 35 (Suppl 7): S269-S271.CrossRefPubMed
16.
go back to reference ISTAT: Annuario Statistico Italiano. 2005, Rome, Italy: ISTAT ISTAT: Annuario Statistico Italiano. 2005, Rome, Italy: ISTAT
17.
go back to reference Milan G: I suicidi nel Veneto. Boll Inf Sist Epidem Reg Veneto. 2008, 3: 5-8. Milan G: I suicidi nel Veneto. Boll Inf Sist Epidem Reg Veneto. 2008, 3: 5-8.
19.
go back to reference Italian Ministery of Health: Rapporto Annuale sull'attività di ricovero ospedaliero. 2005, Rome, Italy: Ministero della Salute Italian Ministery of Health: Rapporto Annuale sull'attività di ricovero ospedaliero. 2005, Rome, Italy: Ministero della Salute
20.
go back to reference WHO Collaborating Centre for Drug Statistic Methodology: Guidelines for ATC Classification and DDD Assignment. 2003, Oslo, Norway: WHO Collaborating Centre for Drug Statistic Methodology WHO Collaborating Centre for Drug Statistic Methodology: Guidelines for ATC Classification and DDD Assignment. 2003, Oslo, Norway: WHO Collaborating Centre for Drug Statistic Methodology
21.
go back to reference Preti A, Miotto P: Increase in first admissions for schizophrenia and other major psychoses in Italy. Psychiatry Res. 2000, 94: 139-52. 10.1016/S0165-1781(00)00136-0.CrossRefPubMed Preti A, Miotto P: Increase in first admissions for schizophrenia and other major psychoses in Italy. Psychiatry Res. 2000, 94: 139-52. 10.1016/S0165-1781(00)00136-0.CrossRefPubMed
22.
go back to reference Barbui C, Broglio E, Laia AC, D'Agostino S, Enrico F, Ferraro L, Fiorio E, Miletti F, Pietraru C, Poggio L, Tognoni G: Cross-sectional database analysis of antidepressant prescribing in Italy. J Clin Psychopharmacol. 2003, 23: 31-34. 10.1097/00004714-200302000-00006.CrossRefPubMed Barbui C, Broglio E, Laia AC, D'Agostino S, Enrico F, Ferraro L, Fiorio E, Miletti F, Pietraru C, Poggio L, Tognoni G: Cross-sectional database analysis of antidepressant prescribing in Italy. J Clin Psychopharmacol. 2003, 23: 31-34. 10.1097/00004714-200302000-00006.CrossRefPubMed
23.
go back to reference Trifirò G, Barbui C, Spina E, Moretti S, Tari M, Alacqua M, Caputi AP, UVEC group, Arcoraci V: Antidepressant drugs: prevalence incidence and indication of use in general practice of Southern Italy during the years 2003-2004. Pharmacoepidemiol Drug Saf. 2007, 16: 552-559. 10.1002/pds.1303.CrossRefPubMed Trifirò G, Barbui C, Spina E, Moretti S, Tari M, Alacqua M, Caputi AP, UVEC group, Arcoraci V: Antidepressant drugs: prevalence incidence and indication of use in general practice of Southern Italy during the years 2003-2004. Pharmacoepidemiol Drug Saf. 2007, 16: 552-559. 10.1002/pds.1303.CrossRefPubMed
24.
go back to reference Castelpietra G, Morsanutto A, Pascolo-Fabrici E, Isacsson G: Antidepressant use and suicide prevention: a prescription database study in the region Friuli-Venezia Giulia Italy. Acta Psychiatr Scand. 2008, 118: 382-388. 10.1111/j.1600-0447.2008.01240.x.CrossRefPubMed Castelpietra G, Morsanutto A, Pascolo-Fabrici E, Isacsson G: Antidepressant use and suicide prevention: a prescription database study in the region Friuli-Venezia Giulia Italy. Acta Psychiatr Scand. 2008, 118: 382-388. 10.1111/j.1600-0447.2008.01240.x.CrossRefPubMed
25.
go back to reference Kupfer DJ, Frank E, Perel JM: The advantage of early treatment intervention in recurrent depression. Arch Gen Psychiatry. 1989, 46: 771-775.CrossRefPubMed Kupfer DJ, Frank E, Perel JM: The advantage of early treatment intervention in recurrent depression. Arch Gen Psychiatry. 1989, 46: 771-775.CrossRefPubMed
26.
go back to reference Munoz-Arroyo R, Sutton M: Exploring potential explanations for the increase in antidepressant prescribing in Scotland using secondary analyses of routine data. Br J Gen Pract. 2006, 56: 423-428.PubMedCentralPubMed Munoz-Arroyo R, Sutton M: Exploring potential explanations for the increase in antidepressant prescribing in Scotland using secondary analyses of routine data. Br J Gen Pract. 2006, 56: 423-428.PubMedCentralPubMed
27.
go back to reference Vichi M, Masocco M, Pompili M, Lester D, Tatarelli R, Vanacore N: Suicide mortality in Italy 1980-2002. Psychiatry Res. 2010, 175: 89-97. 10.1016/j.psychres.2008.12.008.CrossRefPubMed Vichi M, Masocco M, Pompili M, Lester D, Tatarelli R, Vanacore N: Suicide mortality in Italy 1980-2002. Psychiatry Res. 2010, 175: 89-97. 10.1016/j.psychres.2008.12.008.CrossRefPubMed
28.
go back to reference Khan A, Khan S, Kolts R, Brown WA: Suicide rates in clinical trials of SSRIs other antidepressants and placebo: analysis of FDA reports. Am J Psychiatry. 2003, 160: 790-792. 10.1176/appi.ajp.160.4.790.CrossRefPubMed Khan A, Khan S, Kolts R, Brown WA: Suicide rates in clinical trials of SSRIs other antidepressants and placebo: analysis of FDA reports. Am J Psychiatry. 2003, 160: 790-792. 10.1176/appi.ajp.160.4.790.CrossRefPubMed
29.
go back to reference Ciuna A, Andretta M, Corbari L, Levi D, Mirandola M, Sorio A, Barbui C: Are we going to increase the use of antidepressants up to that of benzodiazepines?. Eur J Clin Pharmacol. 2004, 60: 629-634. 10.1007/s00228-004-0810-8.CrossRefPubMed Ciuna A, Andretta M, Corbari L, Levi D, Mirandola M, Sorio A, Barbui C: Are we going to increase the use of antidepressants up to that of benzodiazepines?. Eur J Clin Pharmacol. 2004, 60: 629-634. 10.1007/s00228-004-0810-8.CrossRefPubMed
30.
go back to reference Brown C, Schulberg HC, Madonia MJ, Shear MK, Houck PR: Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders. Am J Psychiatry. 1996, 153: 1293-1300.CrossRefPubMed Brown C, Schulberg HC, Madonia MJ, Shear MK, Houck PR: Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders. Am J Psychiatry. 1996, 153: 1293-1300.CrossRefPubMed
31.
go back to reference Hor K, Taylor M: Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol. 2010, 24 (Suppl): 81-90. 10.1177/1359786810385490.PubMedCentralCrossRefPubMed Hor K, Taylor M: Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol. 2010, 24 (Suppl): 81-90. 10.1177/1359786810385490.PubMedCentralCrossRefPubMed
32.
go back to reference McIntyre RS, Muzina DJ, Kemp DE, Blank D, Woldeyohannes HO, Lofchy J, Soczynska JK, Banik S, Konarski JZ: Bipolar disorder and suicide: research synthesis and clinical translation. Curr Psychiatry Rep. 2008, 10: 66-72. 10.1007/s11920-008-0012-7.CrossRefPubMed McIntyre RS, Muzina DJ, Kemp DE, Blank D, Woldeyohannes HO, Lofchy J, Soczynska JK, Banik S, Konarski JZ: Bipolar disorder and suicide: research synthesis and clinical translation. Curr Psychiatry Rep. 2008, 10: 66-72. 10.1007/s11920-008-0012-7.CrossRefPubMed
33.
go back to reference Vijayakumar L, Kumar MS, Vijayakumar V: Substance use and suicide. Curr Opin Psychiatry. 2011, 24: 197-202. 10.1097/YCO.0b013e3283459242.CrossRefPubMed Vijayakumar L, Kumar MS, Vijayakumar V: Substance use and suicide. Curr Opin Psychiatry. 2011, 24: 197-202. 10.1097/YCO.0b013e3283459242.CrossRefPubMed
Metadata
Title
Sales of antidepressants, suicides and hospital admissions for depression in Veneto Region, Italy, from 2000 to 2005: an ecological study
Authors
Giuseppe Guaiana
Margherita Andretta
Eric Griez
Bruno Biancosino
Luigi Grassi
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2011
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/1744-859X-10-24

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