Top

Published in:

Open Access 01-02-2011 | Poster presentation

Safety, pharmacokinetics, and pharmacodynamics of 4-hour intravenous infusion of eritoran tetrasodium in healthy Japanese and Caucasian males

Authors: Y Okubo, N Aikawa, M Lynn, DP Rossignol, YN Wong, E Schuck, Y Kitahara, T Nakano, O Sivak, KM Wasan, C Nagy

Published in: Critical Care | Special Issue 1/2011

Excerpt

Activation of TLR4 signaling by endotoxin is believed to be a primary mediator of sepsis and septic shock, via excessive production of cytokines and proinflammatory mediators [1]. Eritoran tetrasodium (hereafter eritoran), a synthetic analog of the endotoxin constituent lipid A, binds to the TLR4/MD-2 complex and thereby blocks the interaction of endotoxin with TLR4 [2]. Eritoran is being investigated for the treatment of severe sepsis [3]. We report results of a study conducted to assess the single-dose safety and tolerability, as well as pharmacokinetics and pharmacodynamics, of eritoran infusion in Japanese and Caucasian healthy adult males. …

Opal SM: Int J Med Microbiol. 2007, 297: 365-377. 10.1016/j.ijmm.2007.03.006CrossRefPubMed

Kim HM, et al.: Cell. 2007, 130: 906-917. 10.1016/j.cell.2007.08.002CrossRefPubMed

ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients with Severe Sepsis.[http://clinicaltrials.gov/ct2/show/NCT00334828?term=eritoran&rank=2]]

Title: Safety, pharmacokinetics, and pharmacodynamics of 4-hour intravenous infusion of eritoran tetrasodium in healthy Japanese and Caucasian males
Authors: Y Okubo
N Aikawa
M Lynn
DP Rossignol
YN Wong
E Schuck
Y Kitahara
T Nakano
O Sivak
KM Wasan
C Nagy
Publication date: 01-02-2011
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc9685

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Safety, pharmacokinetics, and pharmacodynamics of 4-hour intravenous infusion of eritoran tetrasodium in healthy Japanese and Caucasian males

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 1/2011

Critical care outcome of pulmonary artery hypertension

Stroke and thrombolysis: an old disease with a new approach

Hand-grip test is a good predictor of extubation success in adult ICU patients

Enhanced insulin sensitivity variability in the first 3 days of ICU stay: implications for tight glycemic control

Outcome and complications in infants with respiratory failure: venovenous two-site versus double-lumen ECMO

Effects of sepsis on venous microcirculation: non-invasive evaluation by quantitative near-infrared spectroscopy