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01-06-2018 | Original Article

Safety of regadenoson stress testing in patients with pulmonary hypertension

Authors: Victor M. Moles, MD, Thomas Cascino, MD, Ashraf Saleh, MD, Krasimira Mikhova, MD, John J. Lazarus, MD, Michael Ghannam, MD, Hong J. Yun, MD, Matthew Konerman, MD, Richard L. Weinberg, MD, PhD, Edward P. Ficaro, PhD, James R. Corbett, MD, Vallerie V. McLaughlin, MD, Venkatesh L. Murthy, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 3/2018

Abstract

Objectives

We sought to determine the safety of regadenoson stress testing in patients with PH.

Background

PH is increasingly recognized at more advanced ages. As many as one-third of patients with PH have coronary artery disease. Because of their physical limitations, patients with PH are unable to adequately exercise. Regadenoson can potentially have an adverse impact due to their tenuous hemodynamics. Current guidelines suggest performing a coronary angiography in patients with PH who have angina or multiple coronary risk factors.

Methods

We identified 67 consecutive patients with confirmed PH by catheterization (mean PA > 25 mmHg not due to left heart disease) who underwent MPI with regadenoson stress. Medical records were reviewed to determine hemodynamic and ECG response to regadenoson.

Results

No serious events occurred. Common side effects related to regadenoson were observed, dyspnea being the most common (70.6%). No syncope occurred. Heart rate increased from 74.6 ± 14 to 96.3 ± 18.3 bpm, systolic blood pressure increased from 129.8 ± 20.9 to 131.8 ± 31 mmHg, and diastolic blood pressure decreased from 77.1 ± 11.4 to 72.9 ± 15.3 mmHg. There was no ventricular tachycardia, ventricular fibrillation, or second- or third-degree atrioventricular block.

Conclusion

Regadenoson stress MPI appears to be well tolerated and safe in patients with PH.

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Title: Safety of regadenoson stress testing in patients with pulmonary hypertension
Authors: Victor M. Moles, MD
Thomas Cascino, MD
Ashraf Saleh, MD
Krasimira Mikhova, MD
John J. Lazarus, MD
Michael Ghannam, MD
Hong J. Yun, MD
Matthew Konerman, MD
Richard L. Weinberg, MD, PhD
Edward P. Ficaro, PhD
James R. Corbett, MD
Vallerie V. McLaughlin, MD
Venkatesh L. Murthy, MD, PhD
Publication date: 01-06-2018
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 3/2018
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0734-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Safety of regadenoson stress testing in patients with pulmonary hypertension

Abstract

Objectives

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Background

Methods

Results

Conclusion

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