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Journal of Orthopaedic Surgery and Research
Published in: Journal of Orthopaedic Surgery and Research 1/2018

Open Access 01-12-2018 | Research article

Rotator cuff tear healing process with graft augmentation of fascia lata in a rabbit model

Authors: Takeshi Kataoka, Takeshi Kokubu, Tomoyuki Muto, Yutaka Mifune, Atsuyuki Inui, Ryosuke Sakata, Hanako Nishimoto, Yoshifumi Harada, Fumiaki Takase, Yasuhiro Ueda, Takashi Kurosawa, Kohei Yamaura, Ryosuke Kuroda

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2018

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Abstract

Background

Fascia lata augmentation of massive rotator cuff tears has shown good clinical results. However, its biological effect during the early healing process is not clearly understood. The purpose of the study was to evaluate the biological efficacy of fascia lata augmentation during the early healing process of rotator cuff tears using a rabbit rotator cuff defect model.

Methods

The infraspinatus tendon was resected from the greater tuberosity of a rabbit to create a rotator cuff tear. The tendon edge was directly sutured to the humeral head. The rotator cuff repaired site was augmented with a fascia lata autograft (augmentation group, group A). The rotator cuff defect in the contralateral shoulder was repaired without augmentation (reattachment group, group R). A group with intact rotator cuff was set as the control group. Histological examinations and mechanical analysis were conducted 4 and 8 weeks postoperatively.

Results

In the HE staining, the tendon maturing score of group A was higher than that of group R at 4 weeks postoperatively. In the safranin O staining, proteoglycan staining at the repaired enthesis in group A at 4 weeks postoperatively was stronger than that in group R. Picrosirius red staining showed that type III and type I collagen in group A was more strongly expressed than that in group R at 4 weeks postoperatively. The ultimate failure load of the infraspinatus tendon–humeral head complex in group A was statistically higher than that in group R at 4 weeks postoperatively. The ultimate failure load of group A was similar to that of the control group.

Conclusion

The biological and mechanical contribution of fascia lata augmentation for massive rotator cuff tears was analyzed in this study. Type III collagen was reported to be expressed during the tendon healing process. Although the biological action similar to natural ligament healing occurred around the fascia lata grafts, type III collagen was gradually replaced by type I collagen as the tissue matured. Our results suggest that fascia lata augmentation could stimulate biological healing and provide initial fixation strength of the repaired rotator cuff.
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Metadata
Title
Rotator cuff tear healing process with graft augmentation of fascia lata in a rabbit model
Authors
Takeshi Kataoka
Takeshi Kokubu
Tomoyuki Muto
Yutaka Mifune
Atsuyuki Inui
Ryosuke Sakata
Hanako Nishimoto
Yoshifumi Harada
Fumiaki Takase
Yasuhiro Ueda
Takashi Kurosawa
Kohei Yamaura
Ryosuke Kuroda
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2018
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-018-0900-4

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