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Open Access 01-12-2024 | Root Canal Debridement | Research

Interleukin-8 (IL-8) levels in gingival crevicular fluid during root canal treatment of molar teeth with symptomatic irreversible pulpitis: impact of varying sodium hypochlorite concentrations

Authors: Esin Özlek, Gizem Kadı, Nasser Shoshaa, Yusuf Saed, İsmet Meydan

Published in: BMC Oral Health | Issue 1/2024

Abstract

Background

The aim of this study was to evaluate the effect of the use of different NaOCl concentrations (1%, 2.5%, and 5.25%) during root canal treatment of molar teeth with symptomatic irreversible pulpitis on the change of the IL-8 level in gingival crevicular fluid (GFC).

Methods

GCF sampling was performed on experimental tooth with irreversible pulpitis before and after treatment and also contralateral healthy tooth of 54 patients. The patients were divided into three groups according to concentration of NaOCl solution (n = 18); 1%, 2.5%, and 5.25% NaOCl solution. GCF sampling from experimental teeth was repeated one week after root canal treatment. Statistical analysis was performed using Mann-Whitney U, Wilcoxon test, one-way ANOVA and Pearson correlation analysis.

Results

There was a significant correlation between IL-8 levels in GCF samples taken from teeth with pulpitis before treatment and from healthy contralateral teeth (p = .000). Furthermore, the pretreatment IL-8 level was significantly higher than the posttreatment IL-8 level(p < .05). The effect of the NaOCl concentration on the change in IL-8 level betweeen pre and post treatment was not found statistically significant (p > .05).

Conclusions

The use of NaOCl during root canal treatment can effectively reduce the levels of IL-8 in GCF and improve clinical outcomes.

Trial registration

This study was registred in the Institutional Review Board and the Ethics Committee of the University (No:11) on 15/12/2021.

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Title: Interleukin-8 (IL-8) levels in gingival crevicular fluid during root canal treatment of molar teeth with symptomatic irreversible pulpitis: impact of varying sodium hypochlorite concentrations
Authors: Esin Özlek
Gizem Kadı
Nasser Shoshaa
Yusuf Saed
İsmet Meydan
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Root Canal Debridement
Root Canal Debridement
Published in: BMC Oral Health / Issue 1/2024
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-024-04128-6

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Springer Medicine

Interleukin-8 (IL-8) levels in gingival crevicular fluid during root canal treatment of molar teeth with symptomatic irreversible pulpitis: impact of varying sodium hypochlorite concentrations

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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