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Open Access 01-12-2022 | Review

Roles of airway basal stem cells in lung homeostasis and regenerative medicine

Authors: Meirong Wu, Xiaojing Zhang, Yijian Lin, Yiming Zeng

Published in: Respiratory Research | Issue 1/2022

Abstract

Airway basal stem cells (BSCs) in the proximal airways are recognized as resident stem cells capable of self-renewing and differentiating to virtually every pseudostratified epithelium cell type under steady-state and after acute injury. In homeostasis, BSCs typically maintain a quiescent state. However, when exposed to acute injuries by either physical insults, chemical damage, or pathogen infection, the remaining BSCs increase their proliferation rate apace within the first 24 h and differentiate to restore lung homeostasis. Given the progenitor property of airway BSCs, it is attractive to research their biological characteristics and how they maintain homeostatic airway structure and respond to injury. In this review, we focus on the roles of BSCs in lung homeostasis and regeneration, detail the research progress in the characteristics of airway BSCs, the cellular and molecular signaling communications involved in BSCs-related airway repair and regeneration, and further discuss the in vitro models for airway BSC propagation and their applications in lung regenerative medicine therapy.

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Title: Roles of airway basal stem cells in lung homeostasis and regenerative medicine
Authors: Meirong Wu
Xiaojing Zhang
Yijian Lin
Yiming Zeng
Publication date: 01-12-2022
Publisher: BioMed Central
Published in: Respiratory Research / Issue 1/2022
Electronic ISSN: 1465-993X
DOI: https://doi.org/10.1186/s12931-022-02042-5

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Obesity Clinical Trial Summary

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Deep learning for spirometry quality assurance with spirometric indices and curves

Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma

Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange

Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension

Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram construction

Correction to: Relationship between gut microbiota and lung function decline in patients with chronic obstructive pulmonary disease: a 1-year follow-up study

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