Published in:
01-04-2015
Role of thrombophilia testing: con
Author:
Scott M. Stevens
Published in:
Journal of Thrombosis and Thrombolysis
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Issue 3/2015
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Excerpt
Though venous thrombosis was described as early as the 13th century [
1], elucidation of its pathophysiology is credited to the 19th Century German physician, Rudolph Ludwig Karl Virchow [
2]. Virchow described a framework for understanding thrombotic disease: “Virchow’ triad” states that pathologic thrombosis results from vessel injury, blood flow stasis, and hypercoagulability, alone or in combination. His inclusion of hypercoagulability was particularly prescient, given the limited understanding of the biology of the coagulation system at the time he was writing. …