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Current Hypertension Reports

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01-01-2018 | Hypertension and Obesity (E Reisin, Section Editor)

Role of Thioredoxin in Age-Related Hypertension

Authors: Kumuda C. Das, Venkatesh Kundumani-Sridharan, Jaganathan Subramani

Published in: Current Hypertension Reports | Issue 1/2018

Abstract

Purpose of Review

Although the roles of oxidant stress and redox perturbations in hypertension have been the subject of several reviews, role of thioredoxin (Trx), a major cellular redox protein in age-related hypertension remains inadequately reviewed. The purpose of this review is to bring readers up-to-date with current understanding of the role of thioredoxin in age-related hypertension.

Recent Findings

Age-related hypertension is a major underlying cause of several cardiovascular disorders, and therefore, intensive management of blood pressure is indicated in most patients with cardiovascular complications. Recent studies have shown that age-related hypertension was reversed and remained lowered for a prolonged period in mice with higher levels of human Trx (Trx-Tg). Additionally, injection of human recombinant Trx (rhTrx) decreased hypertension in aged wild-type mice that lasted for several days. Both Trx-Tg and aged wild-type mice injected with rhTrx were normotensive, showed increased NO production, decreased arterial stiffness, and increased vascular relaxation. These studies suggest that rhTrx could potentially be a therapeutic molecule to reverse age-related hypertension in humans. The reversal of age-related hypertension by restoring proteins that have undergone age-related modification is conceptually novel in the treatment of hypertension.

Summary

Trx reverses age-related hypertension via maintaining vascular redox homeostasis, regenerating critical vasoregulatory proteins oxidized due to advancing age, and restoring native function of proteins that have undergone age-related modifications with loss-of function. Recent studies demonstrate that Trx is a promising molecule that may ameliorate or reverse age-related hypertension in older adults.

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Title: Role of Thioredoxin in Age-Related Hypertension
Authors: Kumuda C. Das
Venkatesh Kundumani-Sridharan
Jaganathan Subramani
Publication date: 01-01-2018
Publisher: Springer US
Published in: Current Hypertension Reports / Issue 1/2018
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-018-0815-9

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