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01-06-2015 | Review

Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment

Authors: Jay Rappaport, David J. Volsky

Published in: Journal of NeuroVirology | Issue 3/2015

Abstract

Combination antiretroviral therapy (ART) has altered the outcomes of HIV infection in treated populations by greatly reducing the incidence of opportunistic infections, cancer, and HIV-associated dementia. Despite these benefits, treated patients remain at high risk of chronic diseases affecting the peripheral organs and brain. Generally, these morbidities are attributed to persistence of latent HIV in resting T cells, chronic inflammation, and metabolic effects of ART. This review makes the case that monocytes/macrophages warrant attention as persistent reservoirs of HIV under ART, source of systemic and brain inflammation, and important targets for HIV eradication to control chronic HIV diseases.

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Title: Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment
Authors: Jay Rappaport
David J. Volsky
Publication date: 01-06-2015
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 3/2015
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-015-0346-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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