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01-12-2017

Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus

Authors: Zachary B. Zalinger, Ruth Elliott, Susan R. Weiss

Published in: Journal of NeuroVirology | Issue 6/2017

Abstract

The inflammasome, a cytosolic protein complex that mediates the processing and secretion of pro-inflammatory cytokines, is one of the first responders during viral infection. The cytokines secreted following inflammasome activation, which include IL-1 and IL-18, regulate cells of both the innate and adaptive immune system, guiding the subsequent immune responses. In this study, we used murine coronavirus, mouse hepatitis virus (MHV), infection of the central nervous system and liver to assess of the role of the inflammasome and its related cytokines on pathogenesis and host defense during viral infection. Mice lacking all inflammasome signaling due to the absence of caspase-1 and -11 were more vulnerable to infection, with poor survival and elevated viral replication compared to wild-type mice. Mice lacking IL-1 signaling experienced elevated viral replication but similar survival compared to wild-type controls. In the absence of IL-18, mice had elevated viral replication and poor survival, and this protective effect of IL-18 was found to be due to promotion of interferon gamma production in αβ T cells. These data suggest that inflammasome signaling is largely protective during murine coronavirus infection, in large part due to the pro-inflammatory effects of IL-18.

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Title: Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus
Authors: Zachary B. Zalinger
Ruth Elliott
Susan R. Weiss
Publication date: 01-12-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 6/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0574-4

At a glance: The STEP trials

Springer Medicine

Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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