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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 10/2016

01-10-2016 | Review Article

Role of taxanes in advanced prostate cancer

Authors: J. Cassinello, J. Carballido Rodríguez, L. Antón Aparicio

Published in: Clinical and Translational Oncology | Issue 10/2016

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Abstract

Advanced prostate cancer is an androgen-dependent disease for which the initial treatment is an androgen deprivation maneuver. However, some primary resistances to hormonal treatment occur with increasing incidence throughout the evolution of the disease. The taxanes, docetaxel and cabazitaxel, exert their action at multiple levels at the tumor cell: besides inhibiting the mitosis and inducing the cell death, they induce the nuclear accumulation of FOXO1, a potent nuclear factor that acts against the activation of androgen receptor inhibiting the transcription of AR-V7 variant associated with the development of resistances to abiraterone and enzalutamide. Docetaxel, as first-line therapy, and cabazitaxel, as second-line therapy, have demonstrated to increase the survival in castration-resistant prostate cancer. The results from last studies either on high-risk localized disease or on androgen-sensitive tumors demonstrate the increasing role of taxanes at earlier states of prostate cancer.
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Metadata
Title
Role of taxanes in advanced prostate cancer
Authors
J. Cassinello
J. Carballido Rodríguez
L. Antón Aparicio
Publication date
01-10-2016
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 10/2016
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-015-1480-y

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