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Published in:

01-10-2011

Role of Sensitization to Mammalian Serum Albumin in Allergic Disease

Authors: Gennaro Liccardi, Riccardo Asero, Maria D’Amato, Gennaro D’Amato

Published in: Current Allergy and Asthma Reports | Issue 5/2011

Abstract

Serum albumin (SA) constitutes an intriguing puzzle that is involved in allergic sensitizations from different sources and induces different clinical manifestations. In this article, we describe the role of sensitization to SAs in inducing allergic diseases and the complex interactions and cross-reactivity between SA resulting from its presence in various mammalian tissues and fluids. SAs alone are an uncommon cause of allergic sensitization in airways, but these allergenic proteins likely play a significant role as cross-reacting allergens in individuals sensitized to several types of animal dander. SAs are a minor allergen in milk but a major allergen in meats. Recently, bovine SA has been added to the culture medium of spermatozoids used for artificial insemination. As a consequence, some case reports have shown that bovine SA may be a causative agent in severe anaphylaxis after standard intrauterine insemination or in vitro fertilization.

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Title: Role of Sensitization to Mammalian Serum Albumin in Allergic Disease
Authors: Gennaro Liccardi
Riccardo Asero
Maria D’Amato
Gennaro D’Amato
Publication date: 01-10-2011
Publisher: Current Science Inc.
Published in: Current Allergy and Asthma Reports / Issue 5/2011
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-011-0214-7

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Role of Sensitization to Mammalian Serum Albumin in Allergic Disease

Abstract

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