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European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 1/2005

01-01-2005 | Brief Report

Role of quinine in life-threatening Babesia divergens infection successfully treated with clindamycin

Authors: C. Corpelet, P. Vacher, F. Coudore, H. Laurichesse, N. Conort, B. Souweine

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 1/2005

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Excerpt

Reported here is a case of life-threatening infection due to Babesia divergens that was initially treated with quinine and clindamycin, but in which quinine was discontinued after the patient developed severe cardiac toxicity. Despite the fact that therapeutic levels of quinine were not reached prior to discontinuation, the patient recovered on clindamycin therapy. …
Literature
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Homer MJ, Aguilar-Delfin I, Telford SR VIII, Krause PJ, Persing DH (2000) Babesiosis. Clin Microbiol Rev 13:451–469CrossRefPubMed
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Brasseur P, Lecoublet S, Kapel N, Favennec L, Ballet JJ (1996) Quinine in the treatment of Babesia divergens infections in humans. Eur J Clin Microbiol Infect Dis 15:840–841
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Brasseur P, Lecoublet S, Kapel N, Favennec L, Ballet JJ (1998) In vitro evaluation of drug susceptibilities of Babesia divergens isolates. Antimicrob Agents Chemother 42:818–820
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Denes E, Rogez JP, Dardé ML, Weinbreck P (1999) Management of Babesia divergens babesiosis without a complete course of quinine treatment. Eur J Clin Microbiol Infect Dis 18:672–673
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Bateman DN, Blain PG, Woodhouse KW, Rawlins MD, Dyson H, Heyworth R, Prescott LF, Proudfoot AT (1985) Pharmakocinetics and clinical toxicity of quinine overdosage: lack of efficacy of techniques intended to enhance elimination. Quarterly J Med 54:125–131
Metadata
Title
Role of quinine in life-threatening Babesia divergens infection successfully treated with clindamycin
Authors
C. Corpelet
P. Vacher
F. Coudore
H. Laurichesse
N. Conort
B. Souweine
Publication date
01-01-2005
Publisher
Springer-Verlag
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 1/2005
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-004-1270-x

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