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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2010

Open Access 01-12-2010 | Review

Role of platelets in neuroinflammation: a wide-angle perspective

Authors: Lawrence L Horstman, Wenche Jy, Yeon S Ahn, Robert Zivadinov, Amir H Maghzi, Masoud Etemadifar, J Steven Alexander, Alireza Minagar

Published in: Journal of Neuroinflammation | Issue 1/2010

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Abstract

Objectives

This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.

Organization

After a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.

Conclusion

The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research.
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Metadata
Title
Role of platelets in neuroinflammation: a wide-angle perspective
Authors
Lawrence L Horstman
Wenche Jy
Yeon S Ahn
Robert Zivadinov
Amir H Maghzi
Masoud Etemadifar
J Steven Alexander
Alireza Minagar
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2010
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/1742-2094-7-10

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