Published in:
01-08-2013 | Poster presentation
Role of inflammatory caspases in a murine two-hit model of sepsis: analysis of immunosuppression and cognitive impairment
Authors:
Mariana Gisely Amaranteeixeira da Cunha, Danielle Bastos de Albuquerque, Daiane Chaves, Silvio Caetano Alves Júnior, Flora Magno, Patrícia Torres Bozza, Fernando Augusto Bozza, Hugo Caire Castro-Faria-Neto, Rachel Novaes Gomes
Published in:
Critical Care
|
Special Issue 4/2013
Login to get access
Excerpt
Morbidities associated with severe sepsis are serious problems for surviving patients, such as cognitive impairment and immunosuppression. The immunosuppression predisposes the patients to a second infection, which generally is fatal. Several studies have been made to understand the mediators involved with this immunosuppression associated with sepsis. Some data from the literature show that caspase-1 promotes activation of cytokines, such as IL-1β, and actions are inhibited by caspase-12. This study proposes to analyze the role of inflammatory caspases in immunosuppression and cognitive damage associated with a two-hit model of sepsis. …
