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Published in:

01-03-2005

Role of Gastrointestinal Hormones in Neuroblastoma

Authors: W. Clay Gustafson, Ph.D., Brittany B. De Berry, M.D., B. Mark Evers, M.D., Dai H. Chung, M.D.

Published in: World Journal of Surgery | Issue 3/2005

Abstract

As a neuroendocrine tumor, neuroblastoma expresses various gastrointestinal (GI) hormones, such as vasoactive intestinal peptide, gastrin-releasing peptide (GRP), neurotensin, and somatostatin, which exert diverse cellular functions in neuroblastoma. In particular, we have recently found that GRP and its cell surface receptor, GRP-R, are abundantly expressed in neuroblastomas. Moreover, more advanced-stage neuroblastomas demonstrated an increased level of GRP-R, suggesting an important role of GRP in aggressive tumor behavior. This review describes the role of several GI hormones commonly expressed in neuroblastoma and discusses in depth the mitogenic actions of GRP in neuroblastoma. In addition, the molecular mechanisms involved in the GRP-induced stimulation of neuroblastoma cell growth are discussed. Our study results demonstrate a role of GRP as an autocrine/paracrine growth factor and elucidate involvement of specific intracellular signaling, the phosphatidylinositol 3-kinase pathway, in the growth regulation of neuroblastoma.

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Title: Role of Gastrointestinal Hormones in Neuroblastoma
Authors: W. Clay Gustafson, Ph.D.
Brittany B. De Berry, M.D.
B. Mark Evers, M.D.
Dai H. Chung, M.D.
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 3/2005
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-004-7815-4

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Role of Gastrointestinal Hormones in Neuroblastoma

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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