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Tumor Biology
Published in: Tumor Biology 2/2014

01-02-2014 | Review

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis

Authors: Shahab Uddin, Azhar R. Hussain, Omar S. Khan, Khawla S. Al-Kuraya

Published in: Tumor Biology | Issue 2/2014

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Abstract

Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor’s roles in the pathogenesis of colonogenic cancer has been described.
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Metadata
Title
Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis
Authors
Shahab Uddin
Azhar R. Hussain
Omar S. Khan
Khawla S. Al-Kuraya
Publication date
01-02-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 2/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1166-4

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