Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 5/2010

01-10-2010 | Review

Role of dietary fatty acids in mammary gland development and breast cancer

Authors: Mira MacLennan, David WL Ma

Published in: Breast Cancer Research | Issue 5/2010

Login to get access

Abstract

Breast cancer is the most common cancer among women worldwide. Estimates suggest up to 35% of cases may be preventable through diet and lifestyle modification. Growing research on the role of fats in human health suggests that early exposure in life to specific fatty acids, when tissues are particularly sensitive to their environment, can have long-term health impacts. The present review examines the role of dietary fat in mammary gland development and breast cancer throughout the lifecycle. Overall, n-3 polyunsaturated fatty acids have promising cancer-preventive effects when introduced early in life, and warrant further research to elucidate the mechanisms of action.
Appendix
Available only for authorised users
Literature
1.
2.
3.
4.
Kelsey JL, Gammon MD, John EM: Reproductive factors and breast cancer. Epidemiol Rev. 1993, 15: 36-47.PubMed
5.
Michels KB, Trichopoulos D, Robins JM, Rosner BA, Manson JE, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE, Willett WC: Birthweight as a risk factor for breast cancer. Lancet. 1996, 348: 1542-1546.PubMed
6.
van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ: Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000, 152: 514-527.PubMed
7.
De AS, Hilakivi-Clarke L: Timing of dietary estrogenic exposures and breast cancer risk. Ann N Y Acad Sci. 2006, 1089: 14-35.
8.
Hilakivi-Clarke L, Cho E, deAssis S, Olivo S, Ealley E, Bouker KB, Welch JN, Khan G, Clarke R, Cabanes A: Maternal and prepubertal diet, mammary development and breast cancer risk. J Nutr. 2001, 131: 154S-157S.PubMed
9.
Lo CY, Hsieh PH, Chen HF, Su HM: A maternal high-fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in the female offspring than exposure to a high-fat diet in postnatal life. Int J Cancer. 2009, 125: 767-773.PubMed
10.
Popkin BM, Udry JR: Adolescent obesity increases significantly in second and third generation U.S. immigrants: the National Longitudinal Study of Adolescent Health. J Nutr. 1998, 128: 701-706.PubMed
11.
Singh GK, Hiatt RA: Trends and disparities in socioeconomic and behavioural characteristics, life expectancy, and cause-specific mortality of native-born and foreign-born populations in the United States, 1979- 2003. Int J Epidemiol. 2006, 35: 903-919.PubMed
12.
Ziegler RG, Hoover RN, Pike MC, Hildesheim A, Nomura AM, West DW, Wu-Williams AH, Kolonel LN, Horn-Ross PL, Rosenthal JF, Hyer MB: Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst. 1993, 85: 1819-1827.PubMed
13.
Fay MP, Freedman LS, Clifford CK, Midthune DN: Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. Cancer Res. 1997, 57: 3979-3988.PubMed
14.
Chajes V, Thiebaut AC, Rotival M, Gauthier E, Maillard V, Boutron-Ruault MC, Joulin V, Lenoir GM, Clavel-Chapelon F: Association between serum transmonounsaturated fatty acids and breast cancer risk in the E3N-EPIC study. Am J Epidemiol. 2008, 167: 1312-1320.PubMed
15.
Sasaki S, Horacsek M, Kesteloot H: An ecological study of the relationship between dietary fat intake and breast cancer mortality. Prev Med. 1993, 22: 187-202.PubMed
16.
Fiorio PA, Grange C, Antoniotti S, Tomatis C, Merlino A, Bussolati B, Munaron L: Arachidonic acid-induced Ca2+ entry is involved in early steps of tumor angiogenesis. Mol Cancer Res. 2008, 6: 535-545.
17.
Horrocks LA, Yeo YK: Health benefits of docosahexaenoic acid (DHA). Pharmacol Res. 1999, 40: 211-225.PubMed
18.
Burdge G: Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care. 2004, 7: 137-144.PubMed
19.
Harris WS, Mozaffarian D, Lefevre M, Toner CD, Colombo J, Cunnane SC, Holden JM, Klurfeld DM, Morris MC, Whelan J: Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids. J Nutr. 2009, 139: 804S-819S.PubMedPubMedCentral
20.
Shanklin J, Cahoon EB: Desaturation and related modifications of fatty acids. Annu Rev Plant Physiol Plant Mol Biol. 1998, 49: 611-641.PubMed
21.
Russo J, Russo IH: Molecular Basis of Breast Cancer: Prevention and Treatment. 2004, Heidelberg: Springer-Verlag
22.
Ball SM: The development of the terminal end bud in the prepubertal-pubertal mouse mammary gland. Anat Rec. 1998, 250: 459-464.PubMed
23.
Cardiff RD, Wellings SR: The comparative pathology of human and mouse mammary glands. J Mammary Gland Biol Neoplasia. 1999, 4: 105-122.PubMed
24.
Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ: Comparative study of human and rat mammary tumorigenesis. Lab Invest. 1990, 62: 244-278.PubMed
25.
Hilakivi-Clarke L, Clarke R, Onojafe I, Raygada M, Cho E, Lippman M: A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring. Proc Natl Acad Sci USA. 1997, 94: 9372-9377.PubMedPubMedCentral
26.
Hilakivi-Clarke L, Clarke R, Lippman M: The influence of maternal diet on breast cancer risk among female offspring. Nutrition. 1999, 15: 392-401.PubMed
27.
Nagata C, Iwasa S, Shiraki M, Sahashi Y, Shimizu H: Association of maternal fat and alcohol intake with maternal and umbilical hormone levels and birth weight. Cancer Sci. 2007, 98: 869-873.PubMed
28.
Su HM, Hsieh PH, Chen HF: A maternal high n-6 fat diet with fish oil supplementation during pregnancy and lactation in rats decreases breast cancer risk in the female offspring. J Nutr Biochem. 2010, : 1033-1037.
29.
Bourre JM: Dietary omega-3 fatty acids for women. Biomed Pharmacother. 2007, 61: 105-112.PubMed
30.
Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP: Conversion of alphalinolenic acid in humans is influenced by the absolute amounts of alphalinolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr. 2006, 84: 44-53.PubMed
31.
Simopoulos AP: Evolutionary aspects of diet and essential fatty acids. World Rev Nutr Diet. 2001, 88: 18-27.PubMed
32.
Simopoulos AP: The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 2008, 233: 674-688.
33.
Potischman N, Troisi R: In-utero and early life exposures in relation to risk of breast cancer. Cancer Causes Control. 1999, 10: 561-573.PubMed
34.
Sanderson M, Williams MA, Malone KE, Stanford JL, Emanuel I, White E, Daling JR: Perinatal factors and risk of breast cancer. Epidemiology. 1996, 7: 34-37.PubMed
35.
Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM: Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007, 85: 1457-1464.PubMed
36.
Innis SM: Trans fatty intakes during pregnancy, infancy and early childhood. Atheroscler Suppl. 2006, 7: 17-20.PubMed
37.
Li J, Humphreys K, Eriksson L, Czene K, Liu J, Hall P: Effects of childhood body size on breast cancer tumour characteristics. Breast Cancer Res. 2010, 12: R23-PubMedPubMedCentral
38.
Peng JH, Zhu JD, Mi MT, Li FJ, Cai L, Dong JZ, Zhang HX, Zhao Y, Xue RL: Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis. Eur J Cancer Prev. 2010, 19: 110-119.PubMed
39.
Cabanes A, Wang M, Olivo S, deAssis S, Gustafsson JA, Khan G, Hilakivi-Clarke L: Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis. 2004, 25: 741-748.PubMed
40.
Nagasawa H, Yanai R, Shodono M, Nakamura T, Tanabe Y: Effect of neonatally administered estrogen or prolactin on normal and neoplastic mammary growth and serum estradiol-17 beta level in rats. Cancer Res. 1974, 34: 2643-2646.PubMed
41.
Berkey CS, Frazier AL, Gardner JD, Colditz GA: Adolescence and breast carcinoma risk. Cancer. 1999, 85: 2400-2409.PubMed
42.
Baer HJ, Colditz GA, Rosner B, Michels KB, Rich-Edwards JW, Hunter DJ, Willett WC: Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study. Breast Cancer Res. 2005, 7: R314-R325.PubMedPubMedCentral
43.
Okasha M, McCarron P, Gunnell D, Smith GD: Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat. 2003, 78: 223-276.PubMed
44.
Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS: The relation of menarcheal age to obesity in childhood and adulthood: the Bogalusa heart study. BMC Pediatr. 2003, 3: 3-PubMedPubMedCentral
45.
Kinnunen TI, Luoto R, Gissler M, Hemminki E, Hilakivi-Clarke L: Pregnancy weight gain and breast cancer risk. BMC Womens Health. 2004, 4: 7-PubMedPubMedCentral
46.
Olivo SE, Hilakivi-Clarke L: Opposing effects of prepubertal low- and high-fat n-3 polyunsaturated fatty acid diets on rat mammary tumorigenesis. Carcinogenesis. 2005, 26: 1563-1572.PubMed
47.
Goodstine SL, Zheng T, Holford TR, Ward BA, Carter D, Owens PH, Mayne ST: Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women. J Nutr. 2003, 133: 1409-1414.PubMed
48.
Hilakivi-Clarke L, Stoica A, Raygada M, Martin MB: Consumption of a high-fat diet alters estrogen receptor content, protein kinase C activity, and mammary gland morphology in virgin and pregnant mice and female offspring. Cancer Res. 1998, 58: 654-660.PubMed
49.
Hilakivi-Clarke L, Clarke R: Timing of dietary fat exposure and mammary tumorigenesis: role of estrogen receptor and protein kinase C activity. Mol Cell Biochem. 1998, 188: 5-12.PubMed
50.
MacMahon B, Cole P, Lin TM, Lowe CR, Mirra AP, Ravnihar B, Salber EJ, Valaoras VG, Yuasa S: Age at first birth and breast cancer risk. Bull World Health Org. 1970, 43: 209-221.PubMedPubMedCentral
51.
Menendez JA, Lupu R, Colomer R: Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. Eur J Cancer Prev. 2005, 14: 263-270.PubMed
52.
Menendez JA, Vazquez-Martin A, Ropero S, Colomer R, Lupu R: HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the 'fat features' of the 'Mediterranean diet' as an 'anti-HER2 cocktail'. Clin Transl Oncol. 2006, 8: 812-820.PubMed
53.
Senzaki H, Iwamoto S, Ogura E, Kiyozuka Y, Arita S, Kurebayashi J, Takada H, Hioki K, Tsubura A: Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. Anticancer Res. 1998, 18: 1621-1627.PubMed
54.
Colomer R, Menendez JA: Mediterranean diet, olive oil and cancer. Clin Transl Oncol. 2006, 8: 15-21.PubMed
55.
Simopoulos AP: The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence. J Nutr. 2001, 131: 3065S-3073S.PubMed
56.
Rose DP, Connolly JM, Rayburn J, Coleman M: Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. J Natl Cancer Inst. 1995, 87: 587-592.PubMed
57.
Yee LD, Young DC, Rosol TJ, Vanbuskirk AM, Clinton SK: Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARγ ligand rosiglitazone. J Nutr. 2005, 135: 983-988.PubMed
58.
59.
Stoll BA: N-3 fatty acids and lipid peroxidation in breast cancer inhibition. Br J Nutr. 2002, 87: 193-198.PubMed
60.
Chen J, Power KA, Mann J, Cheng A, Thompson LU: Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. Exp Biol Med (Maywood). 2007, 232: 1071-1080.
61.
Hardman WE: Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice. Nutr Cancer. 2007, 57: 177-183.PubMed
62.
Gonzalez MJ: Fish oil, lipid peroxidation and mammary tumor growth. J Am Coll Nutr. 1995, 14: 325-335.PubMed
63.
Hardman WE, Sun L, Short N, Cameron IL: Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis. Cancer Cell Int. 2005, 5: 12-PubMedPubMedCentral
64.
Rose DP, Connolly JM, Coleman M: Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice. Clin Cancer Res. 1996, 2: 1751-1756.PubMed
65.
Kaizer L, Boyd NF, Kriukov V, Tritchler D: Fish consumption and breast cancer risk: an ecological study. Nutr Cancer. 1989, 12: 61-68.PubMed
66.
Terry PD, Rohan TE, Wolk A: Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. Am J Clin Nutr. 2003, 77: 532-543.PubMed
67.
Begin ME, Ells G, Horrobin DF: Polyunsaturated fatty acid-induced cytotoxicity against tumor cells and its relationship to lipid peroxidation. J Natl Cancer Inst. 1988, 80: 188-194.PubMed
68.
Gonzalez MJ, Schemmel RA, Dugan L, Gray JI, Welsch CW: Dietary fish oil inhibits human breast carcinoma growth: a function of increased lipid peroxidation. Lipids. 1993, 28: 827-832.PubMed
69.
Hardman WE, Munoz J, Cameron IL: Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice. Cancer Cell Int. 2002, 2: 10-PubMedPubMedCentral
70.
Welsch CW: Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. Free Radic Biol Med. 1995, 18: 757-773.PubMed
71.
72.
Hilakivi-Clarke L, Olivo SE, Shajahan A, Khan G, Zhu Y, Zwart A, Cho E, Clarke R: Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats. J Nutr. 2005, 135: 2946S-2952S.PubMed
73.
Jump DB, Clarke SD, Thelen A, Liimatta M, Ren B, Badin MV: Dietary fat, genes, and human health. Adv Exp Med Biol. 1997, 422: 167-176.PubMed
74.
Sun H, Berquin IM, Edwards IJ: Omega-3 polyunsaturated fatty acids regulate syndecan-1 expression in human breast cancer cells. Cancer Res. 2005, 65: 4442-4447.PubMed
75.
Olivo-Marston SE, Zhu Y, Lee RY, Cabanes A, Khan G, Zwart A, Wang Y, Clarke R, Hilakivi-Clarke L: Gene signaling pathways mediating the opposite effects of prepubertal low-fat and high-fat n-3 polyunsaturated fatty acid diets on mammary cancer risk. Cancer Prev Res (Phila). 2008, 1: 532-545.
76.
Sauer LA, Dauchy RT, Blask DE, Krause JA, Davidson LK, Dauchy EM: Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. J Nutr. 2005, 135: 2124-2129.PubMed
77.
Bougnoux P, Germain E, Chajes V, Hubert B, Lhuillery C, Le FO, Body G, Calais G: Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. Br J Cancer. 1999, 79: 1765-1769.PubMedPubMedCentral
78.
Calder PC: Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale. Biochimie. 2009, 91: 791-795.PubMed
79.
Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN: Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem. 2003, 278: 14677-14687.PubMed
80.
Kim J, Lim SY, Shin A, Sung MK, Ro J, Kang HS, Lee KS, Kim SW, Lee ES: Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study. BMC Cancer. 2009, 9: 216-PubMedPubMedCentral
81.
La GM, Giammanco S, Di MD, Tabacchi G, Tripoli E, Giammanco M: Omega 3 fatty acids: biological activity and effects on human health. Panminerva Med. 2005, 47: 245-257.
82.
MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC: Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA. 2006, 295: 403-415.PubMed
83.
Schulz M, Hoffmann K, Weikert C, Nothlings U, Schulze MB, Boeing H: Identification of a dietary pattern characterized by high-fat food choices associated with increased risk of breast cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Br J Nutr. 2008, 100: 942-946.PubMed
84.
Witt PM, Christensen JH, Schmidt EB, Dethlefsen C, Tjonneland A, Overvad K, Ewertz M: Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. Cancer Causes Control. 2009, 20: 1715-1721.PubMed
85.
Bagga D, Anders KH, Wang HJ, Glaspy JA: Long-chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer. Nutr Cancer. 2002, 42: 180-185.PubMed
86.
Gago-Dominguez M, Yuan JM, Sun CL, Lee HP, Yu MC: Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: the Singapore Chinese Health Study. Br J Cancer. 2003, 89: 1686-1692.PubMedPubMedCentral
87.
Kuriki K, Hirose K, Wakai K, Matsuo K, Ito H, Suzuki T, Hiraki A, Saito T, Iwata H, Tatematsu M, Tajima K: Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. Int J Cancer. 2007, 121: 377-385.PubMed
88.
Maillard V, Bougnoux P, Ferrari P, Jourdan ML, Pinault M, Lavillonniere F, Body G, Le FO, Chajes V: N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int J Cancer. 2002, 98: 78-83.PubMed
89.
Shannon J, King IB, Moshofsky R, Lampe JW, Gao DL, Ray RM, Thomas DB: Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China. Am J Clin Nutr. 2007, 85: 1090-1097.PubMed
90.
Prentice RL: Measurement error and results from analytic epidemiology: dietary fat and breast cancer. J Natl Cancer Inst. 1996, 88: 1738-1747.PubMed
91.
Wynder EL, Cohen LA, Muscat JE, Winters B, Dwyer JT, Blackburn G: Breast cancer: weighing the evidence for a promoting role of dietary fat. J Natl Cancer Inst. 1997, 89: 766-775.PubMed
92.
Wynder EL, Cohen LA, Winters BL: The challenges of assessing fat intake in cancer research investigations. J Am Diet Assoc. 1997, 97: S5-S8.PubMed
93.
Astorg P, Arnault N, Czernichow S, Noisette N, Galan P, Hercberg S: Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women. Lipids. 2004, 39: 527-535.PubMed
94.
Zeng L, Wu GZ, Goh KJ, Lee YM, Ng CC, You AB, Wang J, Jia D, Hao A, Yu Q, Li B: Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis. PLoS One. 2008, 3: e2329-PubMedPubMedCentral
95.
Kallianpur AR, Lee SA, Gao YT, Lu W, Zheng Y, Ruan ZX, Dai Q, Gu K, Shu XO, Zheng W: Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study. Breast Cancer Res Treat. 2008, 107: 123-132.PubMed
96.
Selenskas SL, Ip MM, Ip C: Similarity between trans fat and saturated fat in the modification of rat mammary carcinogenesis. Cancer Res. 1984, 44: 1321-1326.PubMed
97.
Amaru DL, Field CJ: Conjugated linoleic acid decreases mcf-7 human breast cancer cell growth and insulin-like growth factor-1 receptor levels. Lipids. 2009, 44: 449-458.PubMed
98.
Parodi PW: Cows' milk fat components as potential anticarcinogenic agents. J Nutr. 1997, 127: 1055-1060.PubMed
99.
Thiebaut AC, Chajes V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, Berrino F, Riboli E, Benichou J, Clavel-Chapelon F: Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. Int J Cancer. 2009, 124: 924-931.PubMed
Metadata
Title
Role of dietary fatty acids in mammary gland development and breast cancer
Authors
Mira MacLennan
David WL Ma
Publication date
01-10-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2646

Other articles of this Issue 5/2010

Breast Cancer Research 5/2010 Go to the issue

Research article

Akt is required for Stat5 activation and mammary differentiation

Research article

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

Research article

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Research article

DNA methylation epigenotypes in breast cancer molecular subtypes

Research article

Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment

Research article

RARα1 control of mammary gland ductal morphogenesis and wnt1-tumorigenesis
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits