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Published in:

01-11-2013 | Review Article

Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology

Authors: Ce Dou, Yanfei Yan, Shiwu Dong

Published in: Modern Rheumatology | Issue 6/2013

Abstract

Cadherin-11 is a classic cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion. Cadherin-11 is involved in the function of embryonic development, tissue morphogenesis, tumor invasion and metastasis, and signal transduction. This review summarizes the function of cadherin-11 in synovial joint formation and rheumatoid arthritis (RA), including its relative function with bone and cartilage development and growth plate, synovial, and tendon formation. The role of cadherin-11 in RA is also discussed, both in fibroblasts inflammation and fibroblast-like synoviocyte (FLSs) migration and invasion. The potential of anti-cadherin-11 therapy for RA is introduced in comparison with the other current RA therapies.

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Title: Role of cadherin-11 in synovial joint formation and rheumatoid arthritis pathology
Authors: Ce Dou
Yanfei Yan
Shiwu Dong
Publication date: 01-11-2013
Publisher: Springer Japan
Published in: Modern Rheumatology / Issue 6/2013
Print ISSN: 1439-7595
Electronic ISSN: 1439-7609
DOI: https://doi.org/10.1007/s10165-012-0806-7

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