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Breast Cancer Research
Published in: Breast Cancer Research 5/2000

01-10-2000 | Commentary

Role of BRCAgene dysfunction in breast and ovarian cancer predisposition

Author: Ralph Scully

Published in: Breast Cancer Research | Issue 5/2000

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Abstract

Tumor suppressor genes that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are mutated in the germline. The two major hereditary breast/ovarian cancer predisposition genes, BRCA1 and BRCA2, appear to participate in a common pathway that is involved in the control of homologous recombination and in the maintenance of genomic integrity. How might such functions translate into the specific suppression of cancers of the breast and ovarian epithelia? Recent advances in the study of BRCA1 and BRCA2, discussed herein, have provided new opportunities to address this question.
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Metadata
Title
Role of BRCAgene dysfunction in breast and ovarian cancer predisposition
Author
Ralph Scully
Publication date
01-10-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr76

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