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01-12-2014 | Research Article

Role of astrocytes in thiamine deficiency

Authors: Szeifoul Afadlal, Rémi Labetoulle, Alan S. Hazell

Published in: Metabolic Brain Disease | Issue 4/2014

Abstract

Thiamine deficiency (TD) is the underlying cause of Wernicke’s encephalopathy (WE), an acute neurological disorder characterized by structural damage to key periventricular structures in the brain. Increasing evidence suggests these focal histological lesions may be representative of a gliopathy in which astrocyte-related changes are a major feature of the disorder. These changes include a loss of the glutamate transporters GLT-1 and GLAST concomitant with elevated interstitial glutamate levels, lowered brain pH associated with increased lactate production, decreased levels of GFAP, reduction in the levels of glutamine synthetase, swelling, alterations in levels of aquaporin-4, and disruption of the blood–brain barrier. This review focusses on how these manifestations contribute to the pathophysiology of TD and possibly WE.

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Title: Role of astrocytes in thiamine deficiency
Authors: Szeifoul Afadlal
Rémi Labetoulle
Alan S. Hazell
Publication date: 01-12-2014
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 4/2014
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9571-y

At a glance: The STEP trials

Springer Medicine

Role of astrocytes in thiamine deficiency

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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