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Published in: Current Pain and Headache Reports 5/2016

01-05-2016 | Other Pain (N Vadivelu and A Kaye, Section Editors)

Role of Alternative Therapies for Chronic Pain Syndromes

Authors: Donna-Ann Thomas, Benjamin Maslin, Aron Legler, Erin Springer, Abbas Asgerally, Nalini Vadivelu

Published in: Current Pain and Headache Reports | Issue 5/2016

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Abstract

There is increasing interest in the use of complimentary and alternative medicine (CAM) for the treatment of chronic pain. This review examines alternative and complimentary therapies, which can be incorporated as part of a biopsychosocial approach in the treatment of chronic pain syndromes. In the present investigation, literature from articles indexed on PubMed was evaluated including topics of alternative therapies, complimentary therapies, pain psychology, biofeedback therapy, physical exercise therapies, acupuncture, natural and herbal supplements, whole-body cryotherapy, and smartphone technologies in the treatment of chronic pain syndromes. This review highlights the key role of psychology in the treatment of chronic pain. Cognitive behavior therapy appears to be the most impactful while biofeedback therapy has also been shown to be effective for chronic pain. Exercise therapy has been shown to be effective in short-, intermediate-, and long-term pain states. When compared to that in sham controls, acupuncture has shown some benefit for neck pain immediately after the procedure and in the short term and improvement has also been demonstrated in the treatment of headaches. The role of smartphones and whole-body cryotherapy are new modalities and further studies are needed. Recent literature suggests that several alternate therapies could play a role in the treatment of chronic pain, supporting the biopsychosocial model in the treatment of pain states.
Literature
1.
go back to reference Turk DC, Swanson KS, Tunks ER. Psychological approaches in the treatment of chronic pain patients—when pills, scalpels, and needles are not enough. Can J Psychiatry. 2008;53(4):213–23.PubMed Turk DC, Swanson KS, Tunks ER. Psychological approaches in the treatment of chronic pain patients—when pills, scalpels, and needles are not enough. Can J Psychiatry. 2008;53(4):213–23.PubMed
2.
go back to reference Jensen MP, Turk DC. Contributions of psychology to the understanding and treatment of people with chronic pain: why it matters to ALL psychologists. Am Psychol. 2014;69(2):105–18.CrossRefPubMed Jensen MP, Turk DC. Contributions of psychology to the understanding and treatment of people with chronic pain: why it matters to ALL psychologists. Am Psychol. 2014;69(2):105–18.CrossRefPubMed
3.
go back to reference Stenger EM. Chronic back pain: view from a psychiatrist’s office. Clin J Pain. 1992;8(3):242–6.CrossRefPubMed Stenger EM. Chronic back pain: view from a psychiatrist’s office. Clin J Pain. 1992;8(3):242–6.CrossRefPubMed
4.
go back to reference Katz J, Rosenbloom BN, Fashler S. Chronic pain, psychopathology, and DSM-5 somatic symptom disorder. Can J Psychiatry. 2015;60(4):160–7.PubMedPubMedCentral Katz J, Rosenbloom BN, Fashler S. Chronic pain, psychopathology, and DSM-5 somatic symptom disorder. Can J Psychiatry. 2015;60(4):160–7.PubMedPubMedCentral
5.
go back to reference Hague M, Shenker N. How to investigate: chronic pain. Best Pract Res Clin Rheumatol. 2014;28(6):860–74.CrossRefPubMed Hague M, Shenker N. How to investigate: chronic pain. Best Pract Res Clin Rheumatol. 2014;28(6):860–74.CrossRefPubMed
6.
go back to reference International Association for the Study of Pain. Classification of chronic pain. Pain. 1986;Supp 3:S1–S225. International Association for the Study of Pain. Classification of chronic pain. Pain. 1986;Supp 3:S1–S225.
7.
go back to reference Buchbinder M. All in your head. Oakland: University of California Press; 2015. Buchbinder M. All in your head. Oakland: University of California Press; 2015.
8.••
go back to reference Ehde DM, Dillworth TM, Turner JA. Cognitive-behavioral therapy for individuals with chronic pain: efficacy, innovations, and directions for research. Am Psychol. 2014;69(2):153–66. This reference from the psychology literature provides a comprehensive review of the efficacy, breadth and depth of cognitive behavioral therapy (CBT) as an alternative modality for the management of chronic pain. In addition, it provides analyses of population-specific effects of CBT for different subsets of patients with chronic pain, reflecting the diversity encountered in such patients needing therapy. CrossRefPubMed Ehde DM, Dillworth TM, Turner JA. Cognitive-behavioral therapy for individuals with chronic pain: efficacy, innovations, and directions for research. Am Psychol. 2014;69(2):153–66. This reference from the psychology literature provides a comprehensive review of the efficacy, breadth and depth of cognitive behavioral therapy (CBT) as an alternative modality for the management of chronic pain. In addition, it provides analyses of population-specific effects of CBT for different subsets of patients with chronic pain, reflecting the diversity encountered in such patients needing therapy. CrossRefPubMed
9.
go back to reference Kaiser RS, Mooreville M, Kannan K. Psychological interventions for the management of chronic pain: a review of current evidence. Curr Pain Headache Rep. 2015;19(9):43.CrossRefPubMed Kaiser RS, Mooreville M, Kannan K. Psychological interventions for the management of chronic pain: a review of current evidence. Curr Pain Headache Rep. 2015;19(9):43.CrossRefPubMed
10.
go back to reference McKenna K, Gallagher KA, Forbes PW, Ibeziako P. Ready, set, relax: biofeedback-assisted relaxation training (BART) in a pediatric psychiatry consultation service. Psychosomatics. 2015;56(4):381–9.CrossRefPubMed McKenna K, Gallagher KA, Forbes PW, Ibeziako P. Ready, set, relax: biofeedback-assisted relaxation training (BART) in a pediatric psychiatry consultation service. Psychosomatics. 2015;56(4):381–9.CrossRefPubMed
11.
go back to reference Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10(4):287–333.CrossRefPubMed Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006;10(4):287–333.CrossRefPubMed
12.
go back to reference Freburger JK, Carey TS, Holmes GM. Physical therapy for chronic low back pain in North Carolina: overuse, underuse, or misuse? Phys Ther. 2011;91(4):484–95.CrossRefPubMedPubMedCentral Freburger JK, Carey TS, Holmes GM. Physical therapy for chronic low back pain in North Carolina: overuse, underuse, or misuse? Phys Ther. 2011;91(4):484–95.CrossRefPubMedPubMedCentral
13.
go back to reference Jack K, McLean SM, Moffett JK, Gardiner E. Barriers to treatment adherence in physiotherapy outpatient clinics: a systematic review. Man Ther. 2010;15(3):220–8.CrossRefPubMedPubMedCentral Jack K, McLean SM, Moffett JK, Gardiner E. Barriers to treatment adherence in physiotherapy outpatient clinics: a systematic review. Man Ther. 2010;15(3):220–8.CrossRefPubMedPubMedCentral
14.
go back to reference Hall J, Swinkels A, Briddon J, McCabe CS. Does aquatic exercise relieve pain in adults with neurologic or musculoskeletal disease? A systematic review and meta-analysis of randomized controlled trials. Arch Phys Med Rehabil. 2008;89(5):873–83.CrossRefPubMed Hall J, Swinkels A, Briddon J, McCabe CS. Does aquatic exercise relieve pain in adults with neurologic or musculoskeletal disease? A systematic review and meta-analysis of randomized controlled trials. Arch Phys Med Rehabil. 2008;89(5):873–83.CrossRefPubMed
15.•
go back to reference Hayden JA, van Tulder MW, Malmivaara AV, Koes BW. Meta-analysis: exercise therapy for nonspecific low back pain. Ann Intern Med. 2005;142(9):765–75. This thorough meta-analysis is of important significance as it compares the efficacy of different modalities of exercise therapy, reflecting the variety of different subsets of exercise therapy that serve as individual modalities of alternative therapy for chronic pain. CrossRefPubMed Hayden JA, van Tulder MW, Malmivaara AV, Koes BW. Meta-analysis: exercise therapy for nonspecific low back pain. Ann Intern Med. 2005;142(9):765–75. This thorough meta-analysis is of important significance as it compares the efficacy of different modalities of exercise therapy, reflecting the variety of different subsets of exercise therapy that serve as individual modalities of alternative therapy for chronic pain. CrossRefPubMed
16.
go back to reference Van Middelkoop M, Rubinstein SM, Kuijpers T, et al. A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J. 2011;20(1):19–39.CrossRefPubMedPubMedCentral Van Middelkoop M, Rubinstein SM, Kuijpers T, et al. A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J. 2011;20(1):19–39.CrossRefPubMedPubMedCentral
17.
18.
go back to reference Delitto A, George SZ, Van Dillen LR, et al. Low back pain. J Orthop Sports Phys Ther. 2012;42(4):A1–A57.CrossRefPubMed Delitto A, George SZ, Van Dillen LR, et al. Low back pain. J Orthop Sports Phys Ther. 2012;42(4):A1–A57.CrossRefPubMed
19.
go back to reference Bronfort G, Maiers MJ, Evans RL, et al. Supervised exercise, spinal manipulation, and home exercise for chronic low back pain: a randomized clinical trial. Spine J. 2011;11(7):585–98.CrossRefPubMed Bronfort G, Maiers MJ, Evans RL, et al. Supervised exercise, spinal manipulation, and home exercise for chronic low back pain: a randomized clinical trial. Spine J. 2011;11(7):585–98.CrossRefPubMed
20.
go back to reference FitzGerald MP, Anderson RU, Potts J, et al. Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes. J Urol. 2009;182(2):570–80.CrossRefPubMedPubMedCentral FitzGerald MP, Anderson RU, Potts J, et al. Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes. J Urol. 2009;182(2):570–80.CrossRefPubMedPubMedCentral
21.
go back to reference Cornel EB, van Haarst EP, Schaarsberg RWMB-G, Geels J. The effect of biofeedback physical therapy in men with chronic pelvic pain syndrome type III. Eur Urol. 2005;47(5):607–11.CrossRefPubMed Cornel EB, van Haarst EP, Schaarsberg RWMB-G, Geels J. The effect of biofeedback physical therapy in men with chronic pelvic pain syndrome type III. Eur Urol. 2005;47(5):607–11.CrossRefPubMed
22.
go back to reference De Laat A, Stappaerts K, Papy S. Counseling and physical therapy as treatment for myofascial pain of the masticatory system. J Orofac Pain. 2003;17(1):42–9.PubMed De Laat A, Stappaerts K, Papy S. Counseling and physical therapy as treatment for myofascial pain of the masticatory system. J Orofac Pain. 2003;17(1):42–9.PubMed
23.
go back to reference McConnell J. The management of chondromalacia patellae: a long term solution. Aust J Physiother. 1986;32(4):215–23.CrossRefPubMed McConnell J. The management of chondromalacia patellae: a long term solution. Aust J Physiother. 1986;32(4):215–23.CrossRefPubMed
24.
go back to reference Crossley K, Bennell K, Green S, Cowan S, McConnell J. Physical therapy for patellofemoral pain: a randomized, double-blinded, placebo-controlled trial. Am J Sports Med. 2002;30(6):857–65.PubMed Crossley K, Bennell K, Green S, Cowan S, McConnell J. Physical therapy for patellofemoral pain: a randomized, double-blinded, placebo-controlled trial. Am J Sports Med. 2002;30(6):857–65.PubMed
25.
go back to reference Dorsher PT. Acupuncture for chronic pain. Tech Reg Anesth Pain Manag. 2011;15(2):55–63.CrossRef Dorsher PT. Acupuncture for chronic pain. Tech Reg Anesth Pain Manag. 2011;15(2):55–63.CrossRef
26.
go back to reference Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report. 2008;12:1–23.PubMed Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report. 2008;12:1–23.PubMed
27.
go back to reference Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002-2012. Natl Health Stat Report. 2015;79:1–16.PubMed Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002-2012. Natl Health Stat Report. 2015;79:1–16.PubMed
28.
go back to reference Austin S, Ramamonjiarivelo Z, Qu H, Ellis-Griffith G. Acupuncture use in the United States: who, where, why, and at what price? Health Mark Q. 2015;32(2):113–28.CrossRefPubMed Austin S, Ramamonjiarivelo Z, Qu H, Ellis-Griffith G. Acupuncture use in the United States: who, where, why, and at what price? Health Mark Q. 2015;32(2):113–28.CrossRefPubMed
30.
go back to reference Zhang Y. American adult acupuncture use: preliminary findings from NHIS 2012 data. J Altern Complement Med. 2014;20(5):A109–10.CrossRef Zhang Y. American adult acupuncture use: preliminary findings from NHIS 2012 data. J Altern Complement Med. 2014;20(5):A109–10.CrossRef
31.
32.
go back to reference Vickers AJ, Cronin AM, Maschino AC, et al. Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med. 2012;172(19):1444–53.CrossRefPubMedPubMedCentral Vickers AJ, Cronin AM, Maschino AC, et al. Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med. 2012;172(19):1444–53.CrossRefPubMedPubMedCentral
33.
go back to reference Manheimer E, White A, Berman B, Forys K, Ernst E. Meta-analysis: acupuncture for low back pain. Ann Intern Med. 2005;142(8):651–63.CrossRefPubMed Manheimer E, White A, Berman B, Forys K, Ernst E. Meta-analysis: acupuncture for low back pain. Ann Intern Med. 2005;142(8):651–63.CrossRefPubMed
35.
go back to reference Witt CM, Pach D, Brinkhaus B, et al. Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form. Forsch Komplementmed. 2009;16(2):91–7.CrossRefPubMed Witt CM, Pach D, Brinkhaus B, et al. Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form. Forsch Komplementmed. 2009;16(2):91–7.CrossRefPubMed
36.
go back to reference MacPherson H, Vertosick E, Lewith G, et al. Influence of control group on effect size in trials of acupuncture for chronic pain: a secondary analysis of an individual patient data meta-analysis. PLoS One. 2014;9(4):e93739.CrossRefPubMedPubMedCentral MacPherson H, Vertosick E, Lewith G, et al. Influence of control group on effect size in trials of acupuncture for chronic pain: a secondary analysis of an individual patient data meta-analysis. PLoS One. 2014;9(4):e93739.CrossRefPubMedPubMedCentral
38.
go back to reference Oltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. Herbal medicine for low-back pain. Cochrane Database Syst Rev. 2014;12:CD004504.PubMed Oltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. Herbal medicine for low-back pain. Cochrane Database Syst Rev. 2014;12:CD004504.PubMed
39.
go back to reference Gagnier JJ. Evidence-informed management of chronic low back pain with herbal, vitamin, mineral, and homeopathic supplements. Spine J. 2008;8(1):70–9.CrossRefPubMed Gagnier JJ. Evidence-informed management of chronic low back pain with herbal, vitamin, mineral, and homeopathic supplements. Spine J. 2008;8(1):70–9.CrossRefPubMed
40.
go back to reference Smolander J, Westerlund T, Uusitalo A, et al. Lung function after acute and repeated exposures to extremely cold air (-110 degrees C) during whole-body cryotherapy. Clin Physiol Funct Imaging. 2006;26:232–4.CrossRefPubMed Smolander J, Westerlund T, Uusitalo A, et al. Lung function after acute and repeated exposures to extremely cold air (-110 degrees C) during whole-body cryotherapy. Clin Physiol Funct Imaging. 2006;26:232–4.CrossRefPubMed
41.
go back to reference Banfi G, Lombardi G, Colombini A, et al. Whole-body cryotherapy in athletes. Sports Med. 2010;40(6):509–17.CrossRefPubMed Banfi G, Lombardi G, Colombini A, et al. Whole-body cryotherapy in athletes. Sports Med. 2010;40(6):509–17.CrossRefPubMed
42.
go back to reference Banfi G, Melegati G, Barassi A, et al. Effects of whole-body cryotherapy on serum mediators of inflammation and serum muscle enzymes in athletes. J Thermal Biol. 2009;34:55–9.CrossRef Banfi G, Melegati G, Barassi A, et al. Effects of whole-body cryotherapy on serum mediators of inflammation and serum muscle enzymes in athletes. J Thermal Biol. 2009;34:55–9.CrossRef
43.
go back to reference Bettoni L, Bonomi F, Zani V, et al. Effects of 15 consecutive cryotherapy sessions on the clinical output of fibromyalgic patients. Clin Rheum. 2013;Sep 32(9):1337–45.CrossRef Bettoni L, Bonomi F, Zani V, et al. Effects of 15 consecutive cryotherapy sessions on the clinical output of fibromyalgic patients. Clin Rheum. 2013;Sep 32(9):1337–45.CrossRef
44.
go back to reference Guillot X, Tordi N, Mourot L, et al. Cryotherapy in inflammatory rheumatic diseases: a systematic review. Exp Rev Clin Immuno. 2014;10(2):281–94.CrossRef Guillot X, Tordi N, Mourot L, et al. Cryotherapy in inflammatory rheumatic diseases: a systematic review. Exp Rev Clin Immuno. 2014;10(2):281–94.CrossRef
45.
go back to reference Chrubasik S, Junck H, Breitschwerdt H, Conradt C, Zappe H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. Eur J Anaesthesiol. 1999;16(2):118–29.CrossRefPubMed Chrubasik S, Junck H, Breitschwerdt H, Conradt C, Zappe H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study. Eur J Anaesthesiol. 1999;16(2):118–29.CrossRefPubMed
46.
go back to reference Chrubasik S, Eisenberg E, Balan E, Weinberger T, Luzzati R, Conradt C. Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study. Am J Med. 2000;109(1):9–14.CrossRefPubMed Chrubasik S, Eisenberg E, Balan E, Weinberger T, Luzzati R, Conradt C. Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study. Am J Med. 2000;109(1):9–14.CrossRefPubMed
47.
go back to reference Frerick H, Keitel W, Kuhn U, Schmidt S, Bredehorst A, Kuhlmann M. Topical treatment of chronic low back pain with a capsicum plaster. Pain. 2003;106(1-2):59–64.CrossRefPubMed Frerick H, Keitel W, Kuhn U, Schmidt S, Bredehorst A, Kuhlmann M. Topical treatment of chronic low back pain with a capsicum plaster. Pain. 2003;106(1-2):59–64.CrossRefPubMed
48.
go back to reference Yip YB, Tse SH. The effectiveness of relaxation acupoint stimulation and acupressure with aromatic lavender essential oil for non-specific low back pain in Hong Kong: a randomised controlled trial. Complement Ther Med. 2004;12(1):28–37.CrossRefPubMed Yip YB, Tse SH. The effectiveness of relaxation acupoint stimulation and acupressure with aromatic lavender essential oil for non-specific low back pain in Hong Kong: a randomised controlled trial. Complement Ther Med. 2004;12(1):28–37.CrossRefPubMed
49.
go back to reference Nicholas J, Larsen ME, Proudfoot J, et al. Mobile apps for bipolar disorder: a systematic review of features and content quality. J Med Internet Res. 2015;17:17(8).CrossRef Nicholas J, Larsen ME, Proudfoot J, et al. Mobile apps for bipolar disorder: a systematic review of features and content quality. J Med Internet Res. 2015;17:17(8).CrossRef
50.•
go back to reference Guillory J, Chang P, Henderson Jr CR, et al. Piloting a text message-based social support intervention for patients with chronic pain: establishing feasibility and preliminary efficacy. Clin J Pain. 2015;31(6):548–56. This study is of key significance as it demonstrates the feasibility of using a novel technology to collect data not only on personalized pain but also the potential to reduce that pain. It also analyzes the text message-based social support intervention as of key potential as an alternative modality of pain management due to its accessibility to patients. CrossRefPubMed Guillory J, Chang P, Henderson Jr CR, et al. Piloting a text message-based social support intervention for patients with chronic pain: establishing feasibility and preliminary efficacy. Clin J Pain. 2015;31(6):548–56. This study is of key significance as it demonstrates the feasibility of using a novel technology to collect data not only on personalized pain but also the potential to reduce that pain. It also analyzes the text message-based social support intervention as of key potential as an alternative modality of pain management due to its accessibility to patients. CrossRefPubMed
51.
go back to reference Hoffman HG, Richards TL, Bills AR, et al. Using fMRI to study the neural correlates of virtual reality analgesia. CNS Spectr. 2006;11(1):45–51.PubMed Hoffman HG, Richards TL, Bills AR, et al. Using fMRI to study the neural correlates of virtual reality analgesia. CNS Spectr. 2006;11(1):45–51.PubMed
53.
go back to reference Barr C, Marois M, Sim I, et al. The PREEMPT study—evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Trials. 2015;16:67.CrossRefPubMedPubMedCentral Barr C, Marois M, Sim I, et al. The PREEMPT study—evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Trials. 2015;16:67.CrossRefPubMedPubMedCentral
54.
go back to reference Blödt S, Pach D, Roll S, et al. Effectiveness of app-based relaxation for patients with chronic low back pain (Relaxback) and chronic neck pain (Relaxneck): study protocol for two randomized pragmatic trials. Trials. 2014;15:490.CrossRefPubMedPubMedCentral Blödt S, Pach D, Roll S, et al. Effectiveness of app-based relaxation for patients with chronic low back pain (Relaxback) and chronic neck pain (Relaxneck): study protocol for two randomized pragmatic trials. Trials. 2014;15:490.CrossRefPubMedPubMedCentral
Metadata
Title
Role of Alternative Therapies for Chronic Pain Syndromes
Authors
Donna-Ann Thomas
Benjamin Maslin
Aron Legler
Erin Springer
Abbas Asgerally
Nalini Vadivelu
Publication date
01-05-2016
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 5/2016
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-016-0562-z

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