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BMC Urology
Published in: BMC Urology 1/2015

Open Access 01-12-2015 | Research article

Role for intravesical prostatic protrusion in lower urinary tract symptom: a fluid structural interaction analysis study

Authors: Junming Zheng, Jiangang Pan, Yi Qin, Jiale Huang, Yun Luo, Xin Gao, Xing Zhou

Published in: BMC Urology | Issue 1/2015

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Abstract

Background

Numerous studies indicated that Intravesical prostatic protrusion is relevant to prognosis of LUTS, however, the confounding effect that is brought about by prostate volume, urethra anterior curvature angle and other factors makes it hard to evaluate the role of intravesical prostatic protrusion in clinical observation.

Methods

We proposed a fluid structural interaction analysis approach. 3D models were constructed based on MRI images, and prostatic urethra diameters were calibrated with urodynamic data. Comparisons of urine flow dynamics were made between models with various degree of intravesical prostatic protrusion, while the intravesical pressure, anterior urethra curvature angle and diameter of prostatic urethra were same among all models to rule out their confounding effects.

Results

Simulation result showed that the decrement of diameter and increment of variation in cross-sectional area for prostatic urethra were related to the degree of intravesical prostatic protrusion. Such deformation would lead to deterioration of flow efficiency and could compromise the effect of bladder outlet obstruction alleviation treatment.

Conclusions

These results provided further evidence for intravesical prostatic protrusion being an independent risk factor for bladder outlet obstruction severity and demonstrated that intravesical prostatic protrusion would be a promising marker in clinical decision making.
Appendix
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Metadata
Title
Role for intravesical prostatic protrusion in lower urinary tract symptom: a fluid structural interaction analysis study
Authors
Junming Zheng
Jiangang Pan
Yi Qin
Jiale Huang
Yun Luo
Xin Gao
Xing Zhou
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2015
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-015-0081-y

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