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Published in: Annals of Surgical Oncology 10/2020

01-10-2020 | Health Services Research and Global Oncology

Robotic Surgery in the Frail Elderly: Analysis of Perioperative Outcomes

Authors: Alessia Aloisi, MD, Jill Tseng, MD, Theresa Kuhn, MD, Jacqueline Feinberg, MD, Dennis S. Chi, MD, Carol L. Brown, MD, Jennifer J. Mueller, MD, Ginger J. Gardner, MD, Oliver Zivanovic, MD, Elizabeth L. Jewell, MD, Kara Long Roche, MD, Vance Broach, MD, Nadeem R. Abu-Rustum, MD, Mario M. Leitao Jr., MD

Published in: Annals of Surgical Oncology | Issue 10/2020

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Abstract

Purpose

The frail are considered at higher risk for unfavorable surgical outcomes (major complications/mortality). We assessed the safety of and outcomes associated with robotic surgery in the frail elderly undergoing gynecologic procedures.

Methods

We identified patients aged ≥ 65 years who underwent a robotic procedure between May 2007 and December 2016. Frailty was defined as the presence of at least three of five frailty factors—more than five comorbidities, low physical activity, weight loss, exhaustion, and fatigue. Perioperative outcomes were recorded. We compared variables among frail and non-frail patients and performed a multivariate logistic regression to detect variables associated with major complications (≥ grade 3) or 90-day mortality.

Results

We identified 982 patients: 71 frail and 911 non-frail patients. Median age was 71 years. Median BMI was 29.8 kg/m2. Thirty-four patients (3.5%) had a 30-day readmission. Seventy-seven (7.8%) had a postoperative complication, of which 23 (2.3%) were major. Ninety-day mortality was 0.5%. There were significant differences with regard to age (P < 0.001), body mass index (BMI) (P < 0.001) and performance status (P < 0.001); the frail were more likely to have had surgery for oncologic reasons (P = 0.047). There were differences in hospital stay (P < 0.001), postoperative (P = 0.042) and major complications (P = 0.007), and 90-day mortality (P = 0.05). At multivariable logistic regression, age ≥ 85 was associated with major complications. BMI, performance status, and major complications were associated with 90-day mortality.

Conclusions

The frail elderly have longer hospital stays and more complications after surgery than the general population, consistent with the reported literature. Careful selection of surgical candidates is required.
Literature
1.
go back to reference Yancik R. Cancer burden in the aged: an epidemiologic and demographic overview. Cancer. 1997;80:1273–83.CrossRef Yancik R. Cancer burden in the aged: an epidemiologic and demographic overview. Cancer. 1997;80:1273–83.CrossRef
2.
go back to reference Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, Sayer AA. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing. 2010;39:197–203.CrossRef Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, Sayer AA. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing. 2010;39:197–203.CrossRef
3.
go back to reference Morley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14:392–7.CrossRef Morley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14:392–7.CrossRef
4.
go back to reference Dodds C, Foo I, Jones K, Singh SK, Waldmann C. Peri-operative care of elderly patients—an urgent need for change: a consensus statement to provide guidance for specialist and non-specialist anaesthetists. Perioper Med Lond. 2013;2:6.CrossRef Dodds C, Foo I, Jones K, Singh SK, Waldmann C. Peri-operative care of elderly patients—an urgent need for change: a consensus statement to provide guidance for specialist and non-specialist anaesthetists. Perioper Med Lond. 2013;2:6.CrossRef
5.
go back to reference Korc-Grodzicki B, Downey RJ, Shahrokni A, Kingham TP, Patel SG, Audision RA. Surgical considerations in older adults with cancer. J Clin Oncol. 2014;32:2647–53.CrossRef Korc-Grodzicki B, Downey RJ, Shahrokni A, Kingham TP, Patel SG, Audision RA. Surgical considerations in older adults with cancer. J Clin Oncol. 2014;32:2647–53.CrossRef
6.
go back to reference Chereau E, Ballester M, Selle F, Rouzier R, Darai E. Ovarian cancer in the elderly: impact of surgery on morbidity and survival. Eur J Surg Oncol. 2011;37:537–42.CrossRef Chereau E, Ballester M, Selle F, Rouzier R, Darai E. Ovarian cancer in the elderly: impact of surgery on morbidity and survival. Eur J Surg Oncol. 2011;37:537–42.CrossRef
7.
go back to reference Aloisi A, Tseng JH, Sandadi S, et al. Is robotic-assisted surgery safe in the elderly population? An analysis of gynecologic procedures in patients ≥ 65 years old. Ann Surg Oncol. 2019;26:244–51.CrossRef Aloisi A, Tseng JH, Sandadi S, et al. Is robotic-assisted surgery safe in the elderly population? An analysis of gynecologic procedures in patients ≥ 65 years old. Ann Surg Oncol. 2019;26:244–51.CrossRef
8.
go back to reference Ballesta Lopez C, Cid JA, Poves I, Bettonica C, Villegas L, Memon MA. Laparoscopic surgery in the elderly patient. Surg Endosc. 2003;17:333–7.CrossRef Ballesta Lopez C, Cid JA, Poves I, Bettonica C, Villegas L, Memon MA. Laparoscopic surgery in the elderly patient. Surg Endosc. 2003;17:333–7.CrossRef
9.
go back to reference Bogani G, Cromi A, Uccella S, et al. Laparoscopic staging in women older than 75 years with early-stage endometrial cancer: comparison with open surgical operation. Menopause. 2014;21:945–51.CrossRef Bogani G, Cromi A, Uccella S, et al. Laparoscopic staging in women older than 75 years with early-stage endometrial cancer: comparison with open surgical operation. Menopause. 2014;21:945–51.CrossRef
10.
go back to reference Bijen CB, Briet JM, de Bock GH, Arts HJ, Bergsma-Kadijk JA, Mourits MJ. Total laparoscopic hysterectomy versus abdominal hysterectomy in the treatment of patients with early-stage endometrial cancer: a randomized multi center study. BMC Cancer. 2009;9:23.CrossRef Bijen CB, Briet JM, de Bock GH, Arts HJ, Bergsma-Kadijk JA, Mourits MJ. Total laparoscopic hysterectomy versus abdominal hysterectomy in the treatment of patients with early-stage endometrial cancer: a randomized multi center study. BMC Cancer. 2009;9:23.CrossRef
11.
go back to reference Walker JL, Piedmonte MR, Spirtos NM, et al. Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 study. J Clin Oncol. 2012;30:695–700.CrossRef Walker JL, Piedmonte MR, Spirtos NM, et al. Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 study. J Clin Oncol. 2012;30:695–700.CrossRef
12.
go back to reference Lin F, Zhang QJ, Zheng FY, et al. Laparoscopically assisted versus open surgery for endometrial cancer—a meta-analysis of randomized controlled trials. Int J Gynecol Cancer. 2008;18:1315–25.CrossRef Lin F, Zhang QJ, Zheng FY, et al. Laparoscopically assisted versus open surgery for endometrial cancer—a meta-analysis of randomized controlled trials. Int J Gynecol Cancer. 2008;18:1315–25.CrossRef
13.
go back to reference Palomba S, Falbo A, Mocciaro R, Russo T, Zullo F. Laparoscopic treatment for endometrial cancer: a meta-analysis of randomized controlled trials (RCTs). Gynecol Oncol. 2009;112:415–21.CrossRef Palomba S, Falbo A, Mocciaro R, Russo T, Zullo F. Laparoscopic treatment for endometrial cancer: a meta-analysis of randomized controlled trials (RCTs). Gynecol Oncol. 2009;112:415–21.CrossRef
14.
go back to reference Kornblith AB, Huang HQ, Walker JL, Spirtos NM, Rotmensch J, Cella D. Quality of life of patients with endometrial cancer undergoing laparoscopic international federation of gynecology and obstetrics staging compared with laparotomy: a Gynecologic Oncology Group study. J Clin Oncol. 2009;27:5337–42.CrossRef Kornblith AB, Huang HQ, Walker JL, Spirtos NM, Rotmensch J, Cella D. Quality of life of patients with endometrial cancer undergoing laparoscopic international federation of gynecology and obstetrics staging compared with laparotomy: a Gynecologic Oncology Group study. J Clin Oncol. 2009;27:5337–42.CrossRef
15.
go back to reference Sarlos D, Kots LA. Robotic versus laparoscopic hysterectomy: a review of recent comparative studies. Curr Opin Obstet Gynecol. 2011;23:283–8.CrossRef Sarlos D, Kots LA. Robotic versus laparoscopic hysterectomy: a review of recent comparative studies. Curr Opin Obstet Gynecol. 2011;23:283–8.CrossRef
16.
go back to reference Sarlos D, Kots L, Stevanovic N, von Felten S, Schar G. Robotic compared with conventional laparoscopic hysterectomy: a randomized controlled trial. Obstet Gynecol. 2012;120:604–11.CrossRef Sarlos D, Kots L, Stevanovic N, von Felten S, Schar G. Robotic compared with conventional laparoscopic hysterectomy: a randomized controlled trial. Obstet Gynecol. 2012;120:604–11.CrossRef
17.
go back to reference Paraiso MF, Ridgeway B, Park AJ, et al. A randomized trial comparing conventional and robotically assisted total laparoscopic hysterectomy. Am J Obstet Gynecol. 2013;208:368 e1–7. Paraiso MF, Ridgeway B, Park AJ, et al. A randomized trial comparing conventional and robotically assisted total laparoscopic hysterectomy. Am J Obstet Gynecol. 2013;208:368 e1–7.
18.
go back to reference Chen SH, Li ZA, Huang R, Xue HQ. Robot-assisted versus conventional laparoscopic surgery for endometrial cancer staging: a meta-analysis. Taiwan J Obstet Gynecol. 2016;55:488–94.CrossRef Chen SH, Li ZA, Huang R, Xue HQ. Robot-assisted versus conventional laparoscopic surgery for endometrial cancer staging: a meta-analysis. Taiwan J Obstet Gynecol. 2016;55:488–94.CrossRef
19.
go back to reference Guy MS, Sheeder J, Behbakht K, Wright JD, Guntupalli SR. Comparative outcomes in older and younger women undergoing laparotomy or robotic surgical staging for endometrial cancer. Am J Obstet Gynecol. 2016;214:350.e1–350.e10.CrossRef Guy MS, Sheeder J, Behbakht K, Wright JD, Guntupalli SR. Comparative outcomes in older and younger women undergoing laparotomy or robotic surgical staging for endometrial cancer. Am J Obstet Gynecol. 2016;214:350.e1–350.e10.CrossRef
20.
go back to reference Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol. 2003;21(7):1383–9.CrossRef Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol. 2003;21(7):1383–9.CrossRef
21.
go back to reference Moore KN, Grainger LS, Smith C, et al. Pathologic findings and outcomes for octogenarians presenting with uterine malignancy. Gynecol Oncol. 2007;106:572–8.CrossRef Moore KN, Grainger LS, Smith C, et al. Pathologic findings and outcomes for octogenarians presenting with uterine malignancy. Gynecol Oncol. 2007;106:572–8.CrossRef
22.
go back to reference Lavoue V, Zeng X, Lau S et al. Impact of robotics on the outcome of elderly patients with endometrial cancer. Gynecol Oncol. 2014;133:556–62.CrossRef Lavoue V, Zeng X, Lau S et al. Impact of robotics on the outcome of elderly patients with endometrial cancer. Gynecol Oncol. 2014;133:556–62.CrossRef
23.
go back to reference Vaknin Z, Perri T, Lau S, et al. Outcome and quality of life in a prospective cohort of the first 100 robotic surgeries for endometrial cancer, with focus on elderly patients. Int J Gynecol Cancer. 2010;20:1367–73.PubMed Vaknin Z, Perri T, Lau S, et al. Outcome and quality of life in a prospective cohort of the first 100 robotic surgeries for endometrial cancer, with focus on elderly patients. Int J Gynecol Cancer. 2010;20:1367–73.PubMed
24.
go back to reference Fried LP, Tangen CM, Walston J, Cardiovascular Health Study Collaborative Research Group, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.CrossRef Fried LP, Tangen CM, Walston J, Cardiovascular Health Study Collaborative Research Group, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.CrossRef
25.
go back to reference Cigolle CT, Ofstedal MB, Tian Z, Blaum CS. Comparing models of frailty: the health and retirement study. J Am Geriatr Soc. 2009;57:830–9.CrossRef Cigolle CT, Ofstedal MB, Tian Z, Blaum CS. Comparing models of frailty: the health and retirement study. J Am Geriatr Soc. 2009;57:830–9.CrossRef
26.
go back to reference Kiely DK, Cupples LA, Lipsitz LA. Validation and comparison of two frailty indexes: the MOBILIZE Boston study. J Am Geriatr Soc. 2009;57:1532–9.CrossRef Kiely DK, Cupples LA, Lipsitz LA. Validation and comparison of two frailty indexes: the MOBILIZE Boston study. J Am Geriatr Soc. 2009;57:1532–9.CrossRef
27.
go back to reference Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007;62:738–43.CrossRef Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007;62:738–43.CrossRef
28.
go back to reference Aubrun F, Marmion F. The elderly patient and postoperative pain treatment. Best Pract Res Clin Anaesthesiol. 2007;21:109–27.CrossRef Aubrun F, Marmion F. The elderly patient and postoperative pain treatment. Best Pract Res Clin Anaesthesiol. 2007;21:109–27.CrossRef
29.
go back to reference Fleming ND, Havrilesky LJ, Valea FA, et al. Analgesic and antiemetic needs following minimally invasive vs open staging for endometrial cancer. Am J Obstet Gynecol. 2011;204:65.e1–65.e6.CrossRef Fleming ND, Havrilesky LJ, Valea FA, et al. Analgesic and antiemetic needs following minimally invasive vs open staging for endometrial cancer. Am J Obstet Gynecol. 2011;204:65.e1–65.e6.CrossRef
30.
go back to reference Dunker S, Hsu HY, Sebag J, et al. Perioperative risk factors for posterior ischemic optic neuropathy. J Am Coll Surg. 2002;194:705–10.CrossRef Dunker S, Hsu HY, Sebag J, et al. Perioperative risk factors for posterior ischemic optic neuropathy. J Am Coll Surg. 2002;194:705–10.CrossRef
31.
go back to reference Frey MK, Ihnow SB, Worley MJ Jr, et al. Minimally invasive staging of endometrial cancer is feasible and safe in elderly women. J Minim Invasive Gynecol. 2011;18:200–4.CrossRef Frey MK, Ihnow SB, Worley MJ Jr, et al. Minimally invasive staging of endometrial cancer is feasible and safe in elderly women. J Minim Invasive Gynecol. 2011;18:200–4.CrossRef
32.
go back to reference Zeng XZ, Lavoue V, Lau S, et al. Outcome of robotic surgery for endometrial cancer as a function of patient age. Int J Gynecol Cancer. 2015;25:637–44.CrossRef Zeng XZ, Lavoue V, Lau S, et al. Outcome of robotic surgery for endometrial cancer as a function of patient age. Int J Gynecol Cancer. 2015;25:637–44.CrossRef
33.
go back to reference Zakhari A, Czuzoj-Shulman N, Spence AR, Gotlieb WH, Abenhaim HA. Hysterectomy for uterine cancer in the elderly: a comparison between laparoscopic and robot-assisted techniques. Int J Gynecol Cancer. 2016;26:1222–7.CrossRef Zakhari A, Czuzoj-Shulman N, Spence AR, Gotlieb WH, Abenhaim HA. Hysterectomy for uterine cancer in the elderly: a comparison between laparoscopic and robot-assisted techniques. Int J Gynecol Cancer. 2016;26:1222–7.CrossRef
34.
go back to reference Bourgin C, Lambaudie E, Houvenaeghel G, Foucher F, Levêque J, Lavoué V. Impact of age on surgical staging and approaches (laparotomy, laparoscopy and robotic surgery) in endometrial cancer management. Eur J Surg Oncol. 2017;43:703–9.CrossRef Bourgin C, Lambaudie E, Houvenaeghel G, Foucher F, Levêque J, Lavoué V. Impact of age on surgical staging and approaches (laparotomy, laparoscopy and robotic surgery) in endometrial cancer management. Eur J Surg Oncol. 2017;43:703–9.CrossRef
35.
go back to reference Backes FJ, ElNaggar AC, Farrell MR, et al. Perioperative outcomes for laparotomy compared to robotic surgical staging of endometrial cancer in the elderly: a retrospective cohort. Int J Gynecol Cancer. 2016;26:1717–21.CrossRef Backes FJ, ElNaggar AC, Farrell MR, et al. Perioperative outcomes for laparotomy compared to robotic surgical staging of endometrial cancer in the elderly: a retrospective cohort. Int J Gynecol Cancer. 2016;26:1717–21.CrossRef
36.
go back to reference Magrina JF, Zanagnolo V, Giles D, et al. Robotic surgical management of endometrial cancer in octogenarians and nonagenarians: analysis of perioperative outcomes and review of the literature. J Robot Surg. 2010;4:109–15.CrossRef Magrina JF, Zanagnolo V, Giles D, et al. Robotic surgical management of endometrial cancer in octogenarians and nonagenarians: analysis of perioperative outcomes and review of the literature. J Robot Surg. 2010;4:109–15.CrossRef
37.
go back to reference Bishop EA, Java J, Moore KN, et al. Operative outcomes among a geriatric population of endometrial cancer patients: an ancillary data analysis of Gynecologic Oncology Group study LAP2 [abstract]. Gynecol Oncol. 2014;133:7.CrossRef Bishop EA, Java J, Moore KN, et al. Operative outcomes among a geriatric population of endometrial cancer patients: an ancillary data analysis of Gynecologic Oncology Group study LAP2 [abstract]. Gynecol Oncol. 2014;133:7.CrossRef
Metadata
Title
Robotic Surgery in the Frail Elderly: Analysis of Perioperative Outcomes
Authors
Alessia Aloisi, MD
Jill Tseng, MD
Theresa Kuhn, MD
Jacqueline Feinberg, MD
Dennis S. Chi, MD
Carol L. Brown, MD
Jennifer J. Mueller, MD
Ginger J. Gardner, MD
Oliver Zivanovic, MD
Elizabeth L. Jewell, MD
Kara Long Roche, MD
Vance Broach, MD
Nadeem R. Abu-Rustum, MD
Mario M. Leitao Jr., MD
Publication date
01-10-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 10/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-08475-w

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