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European Journal of Orthopaedic Surgery & Traumatology

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18-01-2024 | Rivaroxaban | Original Article

Therapy adherence, safety and efficacy of rivaroxaban in prevention of venous thromboembolism in patients with hip or knee endoprosthesis

Authors: Nemanja Tomić, Vladimir Anđić, Dejan Ćurlik, Jovica Čeko, Amna Tanović Avdić, Meliha Mehić, Aziz Šukalo, Una Glamočlija

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 3/2024

Abstract

Purpose

Rivaroxaban is a potent, selective direct inhibitor of factor Xa. The aim of this study was to evaluate the therapy adherence, safety and efficacy of rivaroxaban therapy in reducing the risk of venous thromboembolism in patients undergoing elective hip or knee replacement.

Methods

The prospective, post-marketing clinical trial was conducted on adult patients after knee or hip endoprosthesis. Data were collected at the baseline and three control visits (five days, a month and three months after the baseline). Morisky Medication Adherence Scale (MMAS-8) was used for evaluation of therapy adherence.

Results

The study included 60 patients who received rivaroxaban therapy in a dose of 10 mg once a day. A low adherence to the drug was observed in 15% patients. All patients had an average MMAS-8 score in the range of high adherence 0.65 ± 0.90. Symptomatic venous thromboembolism was observed in two patients with numerous risk factors. No major bleeding was recorded during entire follow-up period. During the five-day postoperative in-hospital follow-up, signs of wound complications were recorded in 8 (13.3%) patients, and 4 (6.7%) of them underwent surgical revision of the wound.

Conclusion

Generally, there was high adherence to rivaroxaban therapy, but low adherence was present in 15% of patients. Rivaroxaban showed good safety and efficacy. However, high proportion of wound complications and patients needing surgical revision of the wound should be further evaluated through larger studies.

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Title: Therapy adherence, safety and efficacy of rivaroxaban in prevention of venous thromboembolism in patients with hip or knee endoprosthesis
Authors: Nemanja Tomić
Vladimir Anđić
Dejan Ćurlik
Jovica Čeko
Amna Tanović Avdić
Meliha Mehić
Aziz Šukalo
Una Glamočlija
Publication date: 18-01-2024
Publisher: Springer Paris
Keywords: Rivaroxaban
Endoprosthesis
Published in: European Journal of Orthopaedic Surgery & Traumatology / Issue 3/2024
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-023-03786-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Therapy adherence, safety and efficacy of rivaroxaban in prevention of venous thromboembolism in patients with hip or knee endoprosthesis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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