Top

Published in:

20-09-2023 | Rituximab | Letter to the Editors

Potential factors associated with a long-term duration of B-cell depletion after using rituximab in patients with nephrotic syndrome

Authors: Cheng Xue, Bing Dai

Published in: Pediatric Nephrology | Issue 3/2024

Excerpt

We read the article “Efficacy and safety of long-term repeated use of rituximab in pediatric patients with nephrotic syndrome” by Choi and colleagues [1] with great interest. Rituximab (RTX) has been widely used in the treatment of various autoimmune and inflammatory conditions, including nephrotic syndrome (NS). RTX is often considered when other treatments have failed or when NS is steroid-dependent. B-cell depletion is the primary mechanism of action of RTX, and the duration of this depletion varies among individuals. Some patients experience a rapid return of B cells, while others have a delayed and gradual reconstitution. …

Choi N, Min J, Kim JH, Kang HG, Ahn YH (2023) Efficacy and safety of long-term repeated use of rituximab in pediatric patients with nephrotic syndrome. Pediatr Nephrol. https://doi.org/10.1007/s00467-023-06124-4CrossRefPubMed

Colucci M, Carsetti R, Cascioli S, Casiraghi F, Perna A, Rava L, Ruggiero B, Emma F, Vivarelli M (2016) B cell reconstitution after rituximab treatment in idiopathic nephrotic syndrome. J Am Soc Nephrol 27:1811–1822CrossRefPubMed

Mescia F, Salviani C, Tonoli M, Affatato S, Moratto D, Tedesco M, Guerini A, Gemmo A, Camoni M, Delbarba E, Zubani R, Garrafa E, Chiarini M, Gregorini G, Scolari F, Alberici F (2023) Sustained post-rituximab B cell depletion is common in ANCA-associated Vasculitis and affected by sex and renal function. Nephrol Dial Transplant. https://doi.org/10.1093/ndt/gfad197CrossRefPubMed

Title: Potential factors associated with a long-term duration of B-cell depletion after using rituximab in patients with nephrotic syndrome
Authors: Cheng Xue
Bing Dai
Publication date: 20-09-2023
Publisher: Springer Berlin Heidelberg
Keywords: Rituximab
Rituximab
Nephrotic Syndrome
Antimetabolite
Published in: Pediatric Nephrology / Issue 3/2024
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06169-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Potential factors associated with a long-term duration of B-cell depletion after using rituximab in patients with nephrotic syndrome

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 3/2024

Use of furosemide in preterm neonates with acute kidney injury is associated with increased mortality: results from the TINKER registry

Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference

Genetics of kidney disorders in Phelan-McDermid syndrome: evidence from 357 registry participants

Multidisciplinary management of people with spina bifida across the lifespan

Mother–child correlation of kidney function: data from the Yamanashi Adjunct Study of Japan Environment and Children’s Study (JECS)

Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference